Hyperlocomotion and anxiety- like behavior induced by binge ethanol exposure in rat neonates. Possible ameliorative effects of Omega 3
| Autor: | Verónica Balaszczuk, Juan Agustín Salguero, Santiago Mendez, Paula Abate, Ruth Noelia Villarreal, Rocio Gala Scaramuzza |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Alcohol Drinking Offspring medicine.medical_treatment Physiology Alcohol Anxiety Binge Drinking 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Pregnancy Fatty Acids Omega-3 medicine Animals Saline 030304 developmental biology chemistry.chemical_classification 0303 health sciences Ethanol business.industry Therapeutic effect medicine.disease Rats Animals Newborn chemistry Fetal Alcohol Spectrum Disorders Prenatal Exposure Delayed Effects Female medicine.symptom business Locomotion 030217 neurology & neurosurgery Polyunsaturated fatty acid |
| Zdroj: | Behavioural Brain Research. 372:112022 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2019.112022 |
| Popis: | Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that can persist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcohol intake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary for normal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3 supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports about acute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goal of this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol (2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg) 15 min after the last alcohol injection. It was have found that EtOH-treated animals showed hyperlocomotion on PND 14 (pre-juvenile), and anxiety-like behavior was observed at all the three ages studied. Administration of omega-3 after EtOH treatment reduced hyperlocomotion and the anxiety-like behaviors on PND 14, but did not diminish the anxiety on either PND 20 or 30 (juvenile). In conclusion, acute ethanol exposure produced neurobehavioral alterations that persisted in the offspring, with omega-3 able to ameliorate these effects on PND 14. These data are relevant considering that omega-3 administration may have therapeutic effects through mitigating some of ethanol´s damaging consequences. |
| Databáze: | OpenAIRE |
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