E and P selectins are not required for resistance to severe murine lyme arthritis
| Autor: | Paul S. Frenette, Richard O. Hynes, Ying Ma, Janis J. Weis, John H. Weis, Kathleen Petri Seiler, Denisa D. Wagner |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Immunology Arthritis Inflammation Lyme Arthritis Microbiology Mice Lyme disease Borrelia burgdorferi Group Synovitis E-selectin medicine Animals Borrelia burgdorferi Mice Knockout Arthritis Infectious Mice Inbred C3H Host Response and Inflammation biology medicine.disease biology.organism_classification bacterial infections and mycoses Immunity Innate Mice Inbred C57BL P-Selectin Infectious Diseases biology.protein Parasitology Female medicine.symptom E-Selectin Selectin Ankle Joint |
| Zdroj: | Infection and immunity. 66(9) |
| ISSN: | 0019-9567 |
| Popis: | Borrelia burgdorferi -induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for their response to infection with B. burgdorferi . E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity. |
| Databáze: | OpenAIRE |
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