Effect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser
| Autor: | Lawrence Chao Shan Chou, Jui-Cheng Chang, Wen Tsan Chang, Chia Yuan Chang, Yi Hsien Liu, Jiu Yao Wang, Chen Han Yang, Wen Shuo Kuo, Shean-Jen Chen, Chang Hsin Chen, Li Chung Cheng |
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| Rok vydání: | 2015 |
| Předmět: |
Indocyanine Green
Methicillin-Resistant Staphylococcus aureus Materials science Cell Survival Metal Nanoparticles Nanotechnology Conjugated system Antibodies law.invention Nanomaterials law Cell Line Tumor Humans General Materials Science Photosensitizer Particle Size Photons Photosensitizing Agents Lasers Size dependent Two photon fluorescence Laser Fluorescence Microscopy Fluorescence Multiphoton Colloidal gold Gold Reactive Oxygen Species |
| Zdroj: | ACS Applied Materials & Interfaces. 7:17318-17329 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.5b04431 |
| Popis: | The photostability, photodestructive efficacy, two-photon excitation cross section, and two-photon fluorescence of gold nanoparticles conjugated with a hydrophilic photosensitizer, indocyanine green, via multiphoton laser exhibited an increased size effect in methicillin-resistant Staphylococcus aureus and A549 cancer cells that was dependent on the size of multifunctional gold nanomaterials, but the effect only occurred when nanomaterials within 100 nm in diameter were used. Besides, the enhanced effectiveness of photodestruction, photostability, and contrast probe indicated an additive effect in the therapeutic and imaging efficiency of multifunctional gold nanomaterials. Consequently, the preparation of the multifunctional gold nanomaterials and their use in biomedical applications via multiphoton laser is an alternative and potential therapeutic approach for killing bacteria and for ablating cancer cells. |
| Databáze: | OpenAIRE |
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