Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
| Autor: | Francisco Rothhammer, Giovanni Poletti, Fuduan Peng, Victor Acuña-Alonzo, Samuel Canizales-Quinteros, Charanya Muralidharan, Nicholas G. Martin, Rolando González-José, Pirro G. Hysi, Krystal Breslin, Li Jin, Susan Walsh, Gu Zhu, Maria C. Bortolini, Wojciech Branicki, Andres Ruiz-Linares, Tamar Nijsten, Kaustubh Adhikari, Ewelina Pośpiech, Sarah E. Medland, Changqing Zeng, M. Arfan Ikram, Shuhua Xu, Carla Gallo, Sijia Wang, Cornelia M. van Duijn, Manfred Kayser, André G. Uitterlinden, Tim D. Spector, Gabriel Bedoya, Merel A. Hamer, Fan Liu, Sijie Wu, Yan Chen |
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| Přispěvatelé: | Department of Physics, National University of Singapore (NUS), King‘s College London, Central South University [Changsha], Molecular Genetics Laboratory, Escuela Nacional de Antropologia y Historia, Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Laboratorio de Genética Molecular, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Facultad de Medicina & Instituto de Alta Investigacion, Universidad de Tarapaca-Universidade de Chile, Departamento de Genética, Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS)-Instituto de Biociencias, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), University of Chinese Academy of Sciences [Beijing] (UCAS), State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, Fudan University [Shanghai]-School of Life Sciences, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Twin Research and Genetic Epidemiology, King's College London, London, Queensland Institute of Medical Research, Forensic Molecular Biology, ErasmusMC, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Dept of Genetics, Evolution and Environment [London] (UCL-GEE), University College of London [London] (UCL), Genetic Identification, Dermatology, Epidemiology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Otras Ciencias Biológicas [SDV]Life Sciences [q-bio] Population [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology Single-nucleotide polymorphism Genome-wide association study Biology Genome Polymorphism Single Nucleotide purl.org/becyt/ford/1 [https] Ciencias Biológicas 03 medical and health sciences Polymorphism (computer science) Native Americans Genetics Journal Article Humans Genetic Predisposition to Disease purl.org/becyt/ford/1.6 [https] education Molecular Biology Genetics (clinical) ComputingMilieux_MISCELLANEOUS Genetic association education.field_of_study Asian Association Studies Articles Regression analysis General Medicine 3. Good health purl.org/pe-repo/ocde/ford#3.01.02 [https] 030104 developmental biology Genes Evolutionary biology Meta-analysis Single Nucleotide Polymorphism native CIENCIAS NATURALES Y EXACTAS americans Genome-Wide Association Study Hair |
| Zdroj: | Human Molecular Genetics Human Molecular Genetics, Oxford University Press (OUP), 2018, 27 (3), pp.559-575. ⟨10.1093/hmg/ddx416⟩ Liu, F, Chen, Y, Zhu, G, Hysi, P G, Wu, S, Adhikari, K, Breslin, K, Pospiech, E, Hamer, M A, Peng, F, Muralidharan, C, Acuna-Alonzo, V, Canizales-Quinteros, S, Bedoya, G, Gallo, C, Poletti, G, Rothhammer, F, Bortolini, M C, Gonzalez-Jose, R, Zeng, C, Xu, S, Jin, L, Uitterlinden, A G, Ikram, M A, van Duijn, C M, Nijsten, T, Walsh, S, Branicki, W, Wang, S, Ruiz-Linares, A, Spector, T D, Martin, N G, Medland, S E & Kayser, M 2017, ' Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddx416 Human Molecular Genetics, 27(3), 559-575. Oxford University Press Human Molecular Genetics, 2018, 27 (3), pp.559-575. ⟨10.1093/hmg/ddx416⟩ CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 0964-6906 1460-2083 |
| DOI: | 10.1093/hmg/ddx416⟩ |
| Popis: | Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P |
| Databáze: | OpenAIRE |
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