Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia
| Autor: | W C Heird, Caraciolo J. Fernandes, S D Reuter, E. O. Smith, Suzanne E Hegemier, Donough J O'Donovan |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Urinary system Metabolite Birth weight Urine Dinoprost behavioral disciplines and activities Gastroenterology Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Predictive Value of Tests Risk Factors Internal medicine mental disorders medicine Birth Weight Humans Infant Very Low Birth Weight Oxygen toxicity Bronchopulmonary Dysplasia F2-Isoprostanes business.industry Infant Newborn Obstetrics and Gynecology Gestational age medicine.disease Prognosis Bronchopulmonary dysplasia chemistry Predictive value of tests Pediatrics Perinatology and Child Health Female business Biomarkers |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association. 27(5) |
| ISSN: | 0743-8346 |
| Popis: | Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F(2)-isoprostanes (F(2)-IsoP). We hypothesized that urinary excretion of the stable metabolite of F(2)-IsoP, 8-iso-PGF(2alpha), would be higher in infants who develop BPD than those who did not.Forty infants30-weeks gestational age (GA) were enrolled, 24 infants with BPD and 16 without BPD. Urine specimens were collected weekly and stored at -80 degrees C until analyzed. Urinary 8-iso-PGF(2alpha) was measured by gas chromatography/mass spectrometry (GC-MS) and normalized to creatinine excretion.GA and birth weight (BW) were lower in infants who developed BPD than those who did not. Urinary 8-iso-PGF(2alpha) levels in the first or third weeks of age were not significantly different between the two groups.Urinary excretion of 8-iso-PGF(2alpha) in early postnatal life in preterm infants is not correlated with the development of BPD. |
| Databáze: | OpenAIRE |
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