Serum sRAGE as a potential biomarker for pediatric bronchiolitis: a pilot study
| Autor: | Alberto García-Salido, Vanesa Gómez-Piña, Juan Casado-Flores, Ana Serrano-González, Gonzalo Oñoro, Gustavo J. Melen, Manuel Ramírez-Orellana |
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| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Time Factors Receptor for Advanced Glycation End Products Pilot Projects Lung injury Intensive Care Units Pediatric Gastroenterology Severity of Illness Index Procalcitonin Pathogenesis chemistry.chemical_compound Patient Admission Predictive Value of Tests Internal medicine White blood cell medicine Humans Prospective Studies Receptors Immunologic Intensive care medicine Pediatric intensive care unit business.industry Age Factors Infant Newborn Infant Length of Stay medicine.disease Prognosis Up-Regulation medicine.anatomical_structure chemistry Bronchiolitis Case-Control Studies Child Preschool Advanced glycation end-product Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Lung. 193(1) |
| ISSN: | 1432-1750 |
| Popis: | Traditional inflammatory biomarkers are insufficient for the evaluation of bronchiolitis severity. Recent investigations have shown that the receptor for advanced glycation end product (RAGE) and its soluble isoforms (sRAGE) play a critical role in the pathogenesis of lung injury. Main objective was to assess the serum levels of sRAGE of children with severe bronchiolitis admitted to the pediatric intensive care unit (PICU). Secondary objective was to study sRAGE correlation with the evolution and traditional biomarkers. Prospective, observational and descriptive study, 43 healthy controls and 37 patients (December 2011–February 2012) were enrolled. sRAGE levels were assessed and compared. In patients, the relation between sRAGE levels and clinical evolution, respiratory assistance, white blood cell count, absolute neutrophils count, serum C-reactive protein, and serum procalcitonin was analyzed. A statistical difference was found in the mean value of sRAGE at PICU admission between patients and controls (1,215.7 ± 535 vs 849 ± 579 pg/ml). Also a significant inverse correlation was found between sRAGE and the Wood–Downes Score at admission (p = 0.02). Serum sRAGE could be elevated in children with bronchiolitis. Larger clinical studies are necessary to elucidate its role as a bronchiolitis inflammatory and/or lung injury biomarker. |
| Databáze: | OpenAIRE |
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