Variation of dominance of newly arisen adaptive genes
| Autor: | Denis Bourguet, Thomas Lenormand, Thomas Guillemaud, Michel Raymond, Didier Fournier, Véronique Marcel |
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| Přispěvatelé: | Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226 |
| Předmět: |
0106 biological sciences
Insecticides Investigations Propoxur 010603 evolutionary biology 01 natural sciences Evolution Molecular Insecticide Resistance 03 medical and health sciences chemistry.chemical_compound Culex pipiens Genotype Genetic variation Genetics Animals Allele Gene 030304 developmental biology Dominance (genetics) Genes Dominant [SDV.GEN]Life Sciences [q-bio]/Genetics 0303 health sciences biology Models Genetic Genetic Variation biology.organism_classification Acetylcholinesterase Adaptation Physiological Culex chemistry |
| Zdroj: | Scopus-Elsevier Europe PubMed Central Genetics Genetics, Genetics Society of America, 1997, 147, pp.1225-1234. ⟨10.1093/genetics/147.3.1225⟩ ResearcherID Genetics, Genetics Society of America, 1997, 147, pp.1225-1234 |
| ISSN: | 0016-6731 |
| DOI: | 10.1093/genetics/147.3.1225⟩ |
| Popis: | Newly arisen adaptive alleles such as insecticide resistance genes represent a good opportunity to investigate the theories put forth to explain the molecular basis of dominance and its possible evolution. Dominance levels of insecticide resistance conferred by insensitive alleles of the acetylcholinesterase gene were analyzed in five resistant strains of the mosquito Culex pipiens. Dominance levels were found to differ between strains, varying from partial recessivity to complete dominance. This variation was not explained by differences in catalytic properties of the enzyme, since four of the five resistant strains had identical inhibition properties for the insensitive acetylcholinesterase. Among these four laboratory strains and in individuals collected from natural populations, we found a correlation between increased acetylcholinesterase activities and higher dominance levels. We propose a molecular explanation for how variation in acetylcholinesterase activity may result in variation of dominance level. We also conjecture that the four resistant strains did not differ in their amino acid sequence in the catalytically active regions of acetylcholinesterase, but that the expression of the gene was regulated by either neighboring or distant sites, thereby modifying the dominance level. Under this interpretation, dominance levels may evolve in this system, since heritable variation in acetylcholinesterase activity was found. |
| Databáze: | OpenAIRE |
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