Spontaneous activity in the piriform cortex extends the dynamic range of cortical odor coding
| Autor: | Helena H.-Y. Huang, Malinda L. S. Tantirigama, John M. Bekkers |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Patch-Clamp Techniques Sensory Receptor Cells Action Potentials Gene Expression Piriform Cortex Sensory system Stimulation Receptors N-Methyl-D-Aspartate Stereotaxic Techniques Mice 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) Piriform cortex medicine Animals Multidisciplinary Neocortex Chemistry musculoskeletal neural and ocular physiology Olfactory Pathways Biological Sciences Olfactory Perception Olfactory Bulb Olfactory bulb Mice Inbred C57BL Smell 030104 developmental biology medicine.anatomical_structure nervous system Odor Odorants NMDA receptor Female Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Proceedings of the National Academy of Sciences. 114:2407-2412 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Neurons in the neocortex exhibit spontaneous spiking activity in the absence of external stimuli, but the origin and functions of this activity remain uncertain. Here, we show that spontaneous spiking is also prominent in a sensory paleocortex, the primary olfactory (piriform) cortex of mice. In the absence of applied odors, piriform neurons exhibit spontaneous firing at mean rates that vary systematically among neuronal classes. This activity requires the participation of NMDA receptors and is entirely driven by bottom-up spontaneous input from the olfactory bulb. Odor stimulation produces two types of spatially dispersed, odor-distinctive patterns of responses in piriform cortex layer 2 principal cells: Approximately 15% of cells are excited by odor, and another approximately 15% have their spontaneous activity suppressed. Our results show that, by allowing odor-evoked suppression as well as excitation, the responsiveness of piriform neurons is at least twofold less sparse than currently believed. Hence, by enabling bidirectional changes in spiking around an elevated baseline, spontaneous activity in the piriform cortex extends the dynamic range of odor representation and enriches the coding space for the representation of complex olfactory stimuli. |
| Databáze: | OpenAIRE |
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