Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats
| Autor: | Ekrem Sezik, Erdem Yesilada, Tetsuro Fujita, Yoshihisa Takaishi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty Turkey Spartium Saponin Gastroenterology Gastric Acid Ingredient In vivo Internal medicine Immersion Drug Discovery Gastric mucosa Animals Medicine Stomach Ulcer Rats Wistar Ligation Pylorus Pharmacology chemistry.chemical_classification Plants Medicinal Ethanol Traditional medicine biology Plant Extracts business.industry Stress ulcer Central Nervous System Depressants Saponins Anti-Ulcer Agents medicine.disease biology.organism_classification digestive system diseases Rats medicine.anatomical_structure chemistry Gastric Mucosa Gastric acid business Stress Psychological |
| Zdroj: | Journal of Ethnopharmacology. 70:219-226 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(99)00180-4 |
| Popis: | Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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