Free-Living Physical Activity and Sedentary Behaviour in Autoimmune Myasthenia Gravis: A Cross-Sectional Study
| Autor: | Jean-Yves Hogrel, Simone Birnbaum, Raphaël Porcher, Damien Bachasson, Pierre Portero, Tarek Sharshar |
|---|---|
| Přispěvatelé: | Institut de Myologie, Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Sorbonne Université (SU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Cross-sectional study [SDV]Life Sciences [q-bio] Physical activity physical activity Motor Activity Spearman's rank correlation coefficient Body Mass Index 03 medical and health sciences 0302 clinical medicine Quality of life Myasthenia Gravis sedentary behaviour medicine accelerometry Humans Prospective Studies Exercise Aged 2. Zero hunger Autoimmune myasthenia gravis business.industry Muscle weakness 030229 sport sciences Middle Aged medicine.disease Trunk Myasthenia gravis Cross-Sectional Studies Neurology quality of life Case-Control Studies Physical therapy Female Neurology (clinical) medicine.symptom Sedentary Behavior business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuromuscular Diseases Journal of Neuromuscular Diseases, IOS Press, 2021, pp.1-9. ⟨10.3233/JND-210637⟩ Journal of Neuromuscular Diseases, 2021, pp.1-9. ⟨10.3233/JND-210637⟩ |
| ISSN: | 2214-3599 2214-3602 |
| Popis: | International audience; Background: Muscle weakness and fatigability, the prominent symptoms of autoimmune myasthenia gravis (MG), impact negatively on daily function and quality of life (QoL). It is currently unclear as to what extent symptoms limit activity and whether physical activity (PA) behaviours are associated with reduced QoL. Objectives: This study aimed to describe habitual PA patterns and explore relationships between PA metrics, clinical MG characteristics, and health-related QoL (HRQoL). Methods: PA data from a trunk tri-axial accelerometer worn for seven days, was collected from females with generalized, stable MG and compared to control subjects. MG-specific evaluations, the six-minute walk test and knee extension strength were assessed in individuals with MG (IwMG). Mann-Whitney tests were used to study between-group differences. Spearman rank correlation coefficient was performed to explore relationships between variables. Results: Thirty-three IwMG (mean (SD) age 45 (11) years) and 66 control subjects were included. IwMG perform less vigorous-intensity PA than control subjects (p = 0.001), spend more time sedentary (p = 0.02) and engage in less and shorter durations of moderate-vigorous-intensity PA (MVPA). For IwMG, habitual PA correlated positively with 6 min walking distance (rho = 0.387, p = 0.029) and negatively with body mass index (rho =-0.407, p = 0.019). We did not find any association between PA or sedentary behaviour and; HRQoL, symptom severity nor lower limb strength. Conclusions: Individuals with stable MG perform less PA, at lower intensities, and are more inactive than controls individuals. Further research is warranted to understand factors influencing PA patterns in MG and whether interventions could be successful in increasing PA quantity and intensity in IwMG. |
| Databáze: | OpenAIRE |
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