Role of optical coherence tomography in the early detection of macular thinning in rheumatoid arthritis patients with chloroquine retinopathy
| Autor: | Tatjana Vulovic, Maja Petrović, Jelena Karadzic, Milan Trenkić, Gordana Stankovic Babic, Marija Trenkić Bozinović |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
rheumatoid arthritis
retina medicine.medical_specialty genetic structures lcsh:Medicine 030209 endocrinology & metabolism chloroquine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography Chloroquine Ophthalmology medicine 030212 general & internal medicine Retina optical coherence tomography medicine.diagnostic_test business.industry lcsh:R Chloroquine retinopathy Hydroxychloroquine Retinal General Medicine medicine.disease eye diseases 3. Good health medicine.anatomical_structure chemistry Rheumatoid arthritis Original Article sense organs business medicine.drug Retinopathy |
| Zdroj: | Journal of Research in Medical Sciences, Vol 24, Iss 1, Pp 55-55 (2019) Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences |
| ISSN: | 1735-1995 |
| Popis: | Background: Chloroquine and hydroxychloroquine are drugs that are primarily used for the treatment of malaria and are also recommended for treating connective tissue disorders, autoimmune diseases, and some dermatological and inflammatory diseases. Treatment with these drugs has potential risk for the development of retinopathy, clinically characterized by bilateral pigment changes in the macula, as one serious ocular complication. The aim of this research was to evaluate the parafoveal and perifoveal macular retinal thickness, as central foveal thickness in adult patients with rheumatoid arthritis (RA) on chloroquine therapy using optical coherence tomography (OCT). Materials and Methods: In this cross-sectional study, 56 RA patients (56 eyes) were included and examined. All patients were treated with chloroquine (tablets resochin or delagil) at a dose of 250 mg/day without treatment with steroids and other immunosuppressive drugs. Patients were divided into two groups, namely, Group I patients - no visible changes in the macula (26 patients) and Group II patients- with visible changes in the macula (30 patients). The central fovea thickness and parafoveal and perifoveal retinal thickness in all quadrants were measured by OCT and compared in both groups. Results: There are a significantly higher number of eyes without thinning of the macula in Group I patients than in Group II (P < 0.001) patients. There are a higher number of patients with recorded parafoveal thinning in Group II patients, especially in the inferior, nasal, and temporal sectors, respectively (P < 0.05). Conclusion: Maculopathy is the main side effect of chloroquine therapy in RA patients that can be detected by OCT in the early stages of the macular involvement. |
| Databáze: | OpenAIRE |
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