Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain
| Autor: | Johanna Silber, Birgit Ohlendorf, Antje Labes, Arlette Erhard, Johannes F. Imhoff |
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| Rok vydání: | 2013 |
| Předmět: |
fungal natural products
Polyesters Pharmaceutical Science Microbial Sensitivity Tests 01 natural sciences Article 03 medical and health sciences Propionibacterium acnes Ascomycota Staphylococcus epidermidis antibiotic Drug Discovery Organic chemistry macrocyclic and linear polyesters Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 030304 developmental biology 0303 health sciences biology Strain (chemistry) Bacteria 010405 organic chemistry Calcarisporium sp 15G256 components marine natural products antibacterial activities Nuclear magnetic resonance spectroscopy biology.organism_classification Xanthomonas campestris 0104 chemical sciences Anti-Bacterial Agents Polyester calcarides A–E lcsh:Biology (General) |
| Zdroj: | Marine Drugs, 11 (9). pp. 3309-3323. Marine Drugs Marine Drugs, Vol 11, Iss 9, Pp 3309-3323 (2013) Marine Drugs; Volume 11; Issue 9; Pages: 3309-3323 |
| Popis: | Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256α, α-2, β, β-2 and π (1–5), and five new derivatives thereof, named calcarides A–E (6–10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed. |
| Databáze: | OpenAIRE |
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