Correlation study between flash dual source CT perfusion imaging and regional lymph node metastasis of non-small cell lung cancer

Autor: Nianlan Cheng, Hui Sun, Qin Lou, Feng Wang, Shuo Wu, Kaiyuan Jin, Xuemei Zhang, Tingting Huang, Bangguo Li, Lv Sun, Xianli Luo
Rok vydání: 2020
Předmět:
Adult
Male
Cancer Research
Lung Neoplasms
Perfusion Imaging
Computed tomography perfusion imaging
Microvessel density
Blood volume
Perfusion scanning
lcsh:RC254-282
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Non-small lung cancer
Predictive Value of Tests
Carcinoma
Non-Small-Cell Lung
Genetics
medicine
Humans
Computed Tomography Perfusion Imaging
Correlation of Data
Lung cancer
Lung
Microvessel
Luminal vessels
Aged
Neoplasm Staging
Lymph node metastasis
Neovascularization
Pathologic
Receiver operating characteristic
business.industry
Blood flow
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Oncology
Lymphatic Metastasis
030220 oncology & carcinogenesis
Microvessels
Preoperative Period
Feasibility Studies
Female
Lymph Nodes
Tomography
X-Ray Computed
business
Nuclear medicine
Perfusion
Research Article
Zdroj: BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
ISSN: 1471-2407
DOI: 10.1186/s12885-020-07032-8
Popis: Background To explore the correlation of flash dual source computed tomography perfusion imaging (CTPI) and regional lymph node metastasis of non-small cell lung cancer (NSCLC), and to evaluate the value of CT perfusion parameters in predicting regional lymph node metastasis of NSCLC. Methods 120 consecutive patients with NSCLC confirmed by postoperative histopathology were underwent flash dual source CT perfusion imaging in pre-operation. The CT perfusion parameters of NSCLC, such as blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability (PMB) were obtained by the image post-processing. Then microvessel density (MVD), luminal vascular number (LVN), luminal vascular area (LVA) and luminal vascular perimeter (LVP) of NSCLC were counted by immunohistochemistry. These cases were divided into group A (patients with lymph node metastasis, 58 cases) and group B (patients without lymph node metastasis, 62 cases) according to their pathological results. The CT perfusion parameters and the microvessel parameters were contrastively analysed between the two groups. Receiver operating characteristic (ROC) curve was used to assess the diagnostic efficiency of CT perfusion parameters in predicting regional lymph node metastasis of NSCLC in pre-operation. Results Group A presented significantly lower LVA, BF and higher MTT, PMB than Group B (P P > 0.05). Correlation analysis showed that BF was correlated with LVA and LVP (P P > 0.05). All the perfusion parameters were not correlated with MVD. According to the ROC curve analysis, when BF Conclusion Flash dual source CT perfusion imaging can non-invasively indicate the luminal vascular structure of tumor and BF can be used as one of the important indexes in predicting regional lymph node metastasis of NSCLC in pre-operation.
Databáze: OpenAIRE
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