Sequentisl induction chemotherapy with vincristine, daunorubicin cyclophosphamide, and prednisone in adult acute lymphoblastic leukemia
| Autor: | Eric Archimbaud, Catherine Sebban, B. Christian, Qk. Bach, N. Gratecos, Y. Bastion, André Bosly, Xavier Thomas, R. Leblay, Bernadette Corront, Denis Fiere, C. Danaïla, Philippe Dufour |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Vincristine Adolescent Cyclophosphamide medicine.medical_treatment Pilot Projects Gastroenterology Prednisone Acute lymphocytic leukemia Internal medicine Antineoplastic Combined Chemotherapy Protocols Confidence Intervals Mucositis Humans Medicine Aged Hyperbilirubinemia Salvage Therapy Chemotherapy business.industry Daunorubicin Remission Induction Induction chemotherapy Nausea Hematology General Medicine Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Anesthesia Adult Acute Lymphoblastic Leukemia Female business medicine.drug |
| Zdroj: | Annals of Hematology. 70:65-69 |
| ISSN: | 1432-0584 0939-5555 |
| Popis: | Sequential chemotherapy with vincristine, daunorubicin, cyclophosphamide, and prednisone doses was administered to 57 adult patients with acute lymphoblastic leukemia (ALL). Complete remission (CR) was achieved in 51 (89%, 95% confidence intervals, [CI] 78-96%). Among patients achieving CR, 62% were in CR after one sequence of chemotherapy, 23% after two sequences, and 5% after three sequences. Six patients (11%) had resistant disease. All patients experienced profound myelosuppression. Median time to recovery of neutrophils0.5 x 10(9)/1 was 22 days (range: 5-89 days), and of platelets100 x 10(9)/1 21 days (range: 0-45 days). Nonhematologic WHO grade 3 or more side effects consisted predominantly of hyperbilirubinemia (7%), mucositis (5%), nausea and vomiting (2%), and cutaneous toxicity (1%). Severe infectious complications occurred in only 14% of cases. One patient (2%, 95% CI 0-9%) died of therapy-related toxicity while in early CR. We concluded that sequential use of prednisone seemed at least as effective as continuous administration at the expense of a few adverse side effects. |
| Databáze: | OpenAIRE |
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