Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: A review of the literature
| Autor: | Alaa Habieb, Marwa Matboli, Omar Abdel-Rahman, Ahmed E. M. Azazy, Nourhan Hossam, Ziad Nagy, Sarah El-Nakeep, Ali E Ebrahim |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Disease Adenocarcinoma Bioinformatics Targeted therapy 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Tumor stage medicine Biomarkers Tumor Humans Molecular Targeted Therapy Topic Highlight Chemotherapy business.industry Gastroenterology Cancer General Medicine medicine.disease Prognosis Molecular biomarkers Response to treatment 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | World journal of gastroenterology. 22(26) |
| ISSN: | 2219-2840 |
| Popis: | Gastric cancer (GC) is a global health problem and a major cause of cancer-related death with high recurrence rates ranging from 25% to 40% for GC patients staging II-IV. Unfortunately, while the majority of GC patients usually present with advanced tumor stage; there is still limited evidence-based therapeutic options. Current approach to GC management consists mainly of; endoscopy followed by, gastrectomy and chemotherapy or chemo-radiotherapy. Recent studies in GC have confirmed that it is a heterogeneous disease. Many molecular characterization studies have been performed in GC. Recent discoveries of the molecular pathways underlying the disease have opened the door to more personalized treatment and better predictable outcome. The identification of molecular markers is a useful tool for clinical managementin GC patients, assisting in diagnosis, evaluation of response to treatment and development of novel therapeutic modalities. While chemotherapeutic agents have certain physiological effects on the tumor cells, the prediction of the response is different from one type of tumor to the other. The specificity of molecular biomarkers is a principal feature driving their application in anticancer therapies. Here we are trying to focus on the role of molecular pathways of GC and well-established molecular markers that can guide the therapeutic management. |
| Databáze: | OpenAIRE |
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