Minimum environmental enrichment is effective in activating antitumor immunity to transplanted tumor cells in mice
| Autor: | Jun-ichiro Komura, Heita Miura, Satoshi Tanaka, Daisaku Takai, Akiko Abe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nervous system Original antitumor immunity Tumor cells Tumor immunity Biology Environment medicine.disease_cause General Biochemistry Genetics and Molecular Biology mouse igloo 03 medical and health sciences Mice 0302 clinical medicine Immune system Neoplasms medicine Animals mouse Environmental enrichment General Veterinary Antitumor immunity Life span General Medicine Housing Animal Cell biology Specific Pathogen-Free Organisms Killer Cells Natural 030104 developmental biology medicine.anatomical_structure environmental enrichment Animal Science and Zoology Female Carcinogenesis 030217 neurology & neurosurgery Neoplasm Transplantation |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | Studies of environmental enrichment are progressing in the fields of nervous system, stress and exercise. Recently, housing in enriched environment have shown to influence to carcinogenesis and life span. However, the study for antitumor effect of environmental enrichment are difficult to reproduce due to the complexity of the experimental technique. Thus, a simpler experiment system is needed for antitumor study using environmental enrichment. In this research, we propose a minimum environmental enrichment, which is an experimental system by placing one mouse igloo which is normally used as a mouse shelter in the rearing environment. The experimental system of minimum environmental enrichment is not only easy to reproduce but also have enhanced activity to suppress the growth of transplanted tumor significantly. It was found that the activation of NK cells is involved also in the immune system related to tumor immunity of minimum environmental enrichment. Because minimum environmental enrichment is effective in activating antitumor immunity to transplanted tumor cells in mice, we believe this will be useful for promoting antitumor studies using environmental enrichment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|