Scalable carbon dioxide electroreduction coupled to carbonylation chemistry
Autor: | Anne K. Ravn, Kim Daasbjerg, Troels Skrydstrup, Rene W. Juhl, Steen Uttrup Pedersen, Magnus H. Rønne, Dennis U. Nielsen, Xin-Ming Hu, Mikkel T. Jensen |
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Rok vydání: | 2017 |
Předmět: |
Multidisciplinary
010405 organic chemistry Chemistry Science General Physics and Astronomy Sonogashira coupling Nanotechnology Homogeneous catalysis General Chemistry 010402 general chemistry Electrochemistry Electrocatalyst 01 natural sciences Combinatorial chemistry Article General Biochemistry Genetics and Molecular Biology 0104 chemical sciences chemistry.chemical_compound Carbon dioxide lcsh:Q lcsh:Science Carbonylation Electrochemical reduction of carbon dioxide Carbon monoxide |
Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017) Jensen, M T, Rønne, M H, Ravn, A K, Juhl, R W, Nielsen, D U, Hu, X, Pedersen, S U, Daasbjerg, K & Skrydstrup, T 2017, ' Scalable carbon dioxide electroreduction coupled to carbonylation chemistry ', Nature Communications, vol. 8, 489 . https://doi.org/10.1038/s41467-017-00559-8 |
ISSN: | 2041-1723 |
Popis: | Significant efforts have been devoted over the last few years to develop efficient molecular electrocatalysts for the electrochemical reduction of carbon dioxide to carbon monoxide, the latter being an industrially important feedstock for the synthesis of bulk and fine chemicals. Whereas these efforts primarily focus on this formal oxygen abstraction step, there are no reports on the exploitation of the chemistry for scalable applications in carbonylation reactions. Here we describe the design and application of an inexpensive and user-friendly electrochemical set-up combined with the two-chamber technology for performing Pd-catalysed carbonylation reactions including amino- and alkoxycarbonylations, as well as carbonylative Sonogashira and Suzuki couplings with near stoichiometric carbon monoxide. The combined two-reaction process allows for milligram to gram synthesis of pharmaceutically relevant compounds. Moreover, this technology can be adapted to the use of atmospheric carbon dioxide. Electroreduction of CO2 to CO is a potential valorisation pathway of carbon dioxide for fine chemicals production. Here, the authors show a user-friendly device that couples CO2 electroreduction with carbonylation chemistry for up to gram scale synthesis of pharmaceuticals even under atmospheric CO2. |
Databáze: | OpenAIRE |
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