Chondroitin sulfate–coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits
| Autor: | Ihsan Gursel, Fatih Eksioglu, Eftal Gudemez, Vasif Hasirci, Petek Korkusuz, Esin Asan |
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| Přispěvatelé: | Kırıkkale Üniversitesi |
| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Time Factors Biocompatibility Biocompatible Materials Tissue Adhesions chemistry.chemical_compound medicine Animals Orthopedics and Sports Medicine Chondroitin sulfate Range of Motion Articular Polyhydroxyethyl Methacrylate chondroitin sulfate polyhydroxyethyl methacrylate (pHEMA) Surgical repair Wound Healing tendon injuries business.industry Chondroitin Sulfates Biomaterial Adhesion musculoskeletal system Tendon Surgery Disease Models Animal Drug Combinations adhesion Tendon sheath medicine.anatomical_structure Membrane chemistry Rabbits business biomaterials Biomedical engineering |
| Zdroj: | The Journal of Hand Surgery. 27:293-306 |
| ISSN: | 0363-5023 |
| DOI: | 10.1053/jhsu.2002.31161 |
| Popis: | KORKUSUZ, PETEK/0000-0002-7553-3915 WOS: 000174437300013 PubMed: 11901389 Polyhydroxyethyl methacrylate (pHEMA) membranes coated on one side with chondroitin sulfate (CS) were used to block adhesion physically and to reduce friction between healing flexor tendons and the surrounding tissue in rabbit forepaws after surgical repair. Digits with pHEMA-only, standard tendon sheath repair, and with no sheath repair were the controls. Over 12 weeks the CS-coated membranes were evaluated for joint flexion, adhesion limitation, and tendon healing progress. The membranes initially allowed for better flexion (i.e, for 6 weeks), but their relative superior effectiveness faded afterward. Histology showed that adhesions were less severe and healing was better in the CS-pHEMA membranes at 3 and 6 weeks. If further studies determine precise amounts or thicknesses of CS coats that will maximize its healing properties, CS-pHEMA should prove useful in clinical settings in which restoration of tendon sheath integrity with a minimum of adhesions is not possible. Copyright (C) 2002 by the American Society for Surgery of the Hand. |
| Databáze: | OpenAIRE |
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