Diagnosis of Malignant Pleural Effusion Using CT Scan and Pleural-Fluid Cytology Together. A Preliminary Case–Control Study
| Autor: | Federica Maffeis, Alessandro Del Conte, Sandro Sulfaro, Paolo Ubiali, Franco Lumachi, Stefano M.M. Basso |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research Biopsy medicine.medical_treatment specificity 0302 clinical medicine pleural effusion Cytology Malignant pleural effusion Cancer Aged 80 and over accuracy medicine.diagnostic_test General Medicine Middle Aged Oncology 030220 oncology & carcinogenesis Female Radiology pleural fluid cytology Adult CT scan medicine.medical_specialty thoracentesis Cytodiagnosis VATS colorectal cancer Thoracentesis Sensitivity and Specificity Diagnosis Differential 03 medical and health sciences breast cancer medicine Thoracoscopy Humans metastasis Lung cancer Aged business.industry Case-control study sensitivity medicine.disease Cancer malignancy pleural effusion metastasis VATS cytology CT scan thoracentesis lung cancer breast cancer colorectal cancer pleural fluid cytology sensitivity specificity accuracy Pleural Effusion Malignant lung cancer Case-Control Studies cytology Differential diagnosis Tomography X-Ray Computed business malignancy |
| Zdroj: | Anticancer Research. 40:1135-1139 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim The purposes of this study were to evaluate the usefulness of chest computed tomographic (CT) scan plus pleural fluid cytology (PFC) together in patients with malignant pleural effusion (PE), and to compare the results of these diagnostic tools in patients with malignant PE due to non-small-cell lung cancer and pulmonary metastases from other malignancies. Patients and methods The medical records of 185 patients with PE, who underwent chest CT, PFC and video-assisted thoracoscopy (VATS) thoracentesis followed by VATS-guided biopsy for diagnostic purpose, were reviewed. At the final diagnosis, 123 (66.5%) patients had malignant PE (cases), and 62 (33.5%) had benign PE (controls). Results Overall, the sensitivity, specificity, and accuracy of CT and PFC were 65.0% vs. 67.5% 98.4% vs. 98.4%, and 76.2% vs. 77.8%, respectively. The combination of CT plus PFC significantly improved sensitivity (86.2%, p=0.003) and accuracy (90.8%, p=0.02). Conclusion CT and PFC used together may lead to approximately 100% specificity and >90% sensitivity in distinguishing between benign and malignant PE. |
| Databáze: | OpenAIRE |
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