Malignant round cell tumor of bone with EWSR1-NFATC2 gene fusion
| Autor: | Raghunath Puthiyaveettil, Svetlana Pack, Julieta E. Barroeta, Navid Sadri, Frederic G. Barr, Bishwanath Chatterjee, Zied Abdullaev, John S. Brooks, Paul J. Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty NFATC2 CD99 Bone Neoplasms EWING SARCOMA BREAKPOINT REGION 1 Sarcoma Ewing Biology Article Curettage Pathology and Forensic Medicine Fusion gene Drug Therapy medicine Humans Molecular Biology Gene Rearrangement Bone Transplantation NFATC Transcription Factors RNA-Binding Proteins Ewing's sarcoma Cell Biology General Medicine medicine.disease Combined Modality Therapy Treatment Outcome NFATC2 Gene Osteosarcoma Calmodulin-Binding Proteins Sarcoma Gene Fusion RNA-Binding Protein EWS biology.gene |
| Zdroj: | Virchows Archiv. 465:233-239 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-014-1613-7 |
| Popis: | Gene rearrangements involving the Ewing sarcoma breakpoint region 1 (EWSR1) gene are seen in a broad range of sarcomas and some nonmesenchymal neoplasms. Ewing sarcoma is molecularly defined by a fusion of the EWSR1 gene (or rarely the related FUS gene) to a member of the E26 transformation-specific (ETS) family of transcription factors, frequently the EWSR1-FLI1 fusion. More recently, EWSR1 gene fusion to non-ETS family members, including the nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 2 (NFATC2) gene, has been reported in a histological variant of Ewing sarcoma. Here, we report a malignant round cell tumor of bone with an EWSR1-NFATC2 fusion gene. This report builds upon the unusual morphological and clinical presentation of bone neoplasms containing an EWSR1-NFATC2 fusion gene. |
| Databáze: | OpenAIRE |
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