Pituitary-adrenal function in ten patients receiving medroxyprogesterone acetate for true precocious puberty
| Autor: | Akira Morishima, Cyril A. L. Abrams, Joan H. Mathews |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
Pituitary gland medicine.medical_specialty Medroxyprogesterone Dose Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Population Pituitary-Adrenal System Puberty Precocious Biochemistry Endocrinology Adrenocorticotropic Hormone Oral administration Internal medicine medicine Precocious puberty Endocrine system Medroxyprogesterone acetate Adrenal function Humans education Child Glucocorticoids 17-Hydroxycorticosteroids education.field_of_study Clinical Trials as Topic Metyrapone business.industry Biochemistry (medical) Obstetrics and Gynecology General Medicine medicine.disease medicine.anatomical_structure True Precocious Puberty Clinical evidence Child Preschool Depression Chemical Pituitary Gland Female Pituitary-Adrenal Function Tests business Hormone medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 30(5) |
| ISSN: | 0021-972X |
| Popis: | The effect of medroxyprogesterone acetate (MPA) on pituitary-adrenal function was investigated in 10 patients with true precocious puberty. Although the patients receiving MPA responded to exogenously administered ACTH by a rise in the plasma 17-hydroxycorticosteroids, the mean values of both the pre- and post-ACTH levels were statistically lower than those obtained in the controls. In 7 of the 8 patients the increase of the urinary 17-ketogenic steroids following the oral administration of metyrapone was less than 2-fold. The data suggest that MPA in the dosages tested has a suppressive effect on pituitary ACTH synthesis and/or release. Despite this inhibition, however, no clinical evidence of hypoadrenocorticism was observed in these patients even during periods of stress. When the drug was discontinued, pituitary-adrenal function rapidly returned toward normal, suggesting that the suppressive effect of MPA was a relatively mild one. |
| Databáze: | OpenAIRE |
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