| Autor: |
Marta Varela-Eirín, Marco Demaria |
| Přispěvatelé: |
Damage and Repair in Cancer Development and Cancer Treatment (DARE), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Current Biology, 32(10), R448-R452. CELL PRESS |
| ISSN: |
0960-9822 |
| DOI: |
10.1016/j.cub.2022.04.003 |
| Popis: |
Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators. This state is crucial in tissue physiology and pathology and arises as a response to potentially damaging stress signals. Whether the activation of a senescence state provides benefits or detriments for tissue function and homeostasis is strictly dependent on the context. Cell senescence acts as a potent tumour-suppressive mechanism limiting the proliferation of cells at risk of malignant transformation and supports the repair of acute tissue damage, but also represents a key driver of ageing and age-related diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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