Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease
| Autor: | Jordi Bella, Judith A. Hoyland, Ari Elson, Mattia Vitale, Iva R. Nedeva |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
collagen
musculoskeletal diseases 0301 basic medicine Cell signaling Bone disease OSCAR 030209 endocrinology & metabolism Review Biology Bone tissue Bone resorption Bone remodeling Cell and Developmental Biology 03 medical and health sciences 0302 clinical medicine Osteoclast medicine cell signaling lcsh:QH301-705.5 osteoclastogenesis bone remodeling Cell Biology medicine.disease Cell biology 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) RANKL biology.protein bone disease osteoclast-associated receptor Signal transduction Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology Nedeva, I, Vitale, M, Elson, A, Hoyland, J & Bella, J 2021, ' Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease ', Front Cell Dev Biol, vol. 9, 641162 . https://doi.org/10.3389/fcell.2021.641162 Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2021.641162 |
| Popis: | Formation of mature bone-resorbing cells through osteoclastogenesis is required for the continuous remodeling and repair of bone tissue. In aging and disease this process may become aberrant, resulting in excessive bone degradation and fragility fractures. Interaction of receptor-activator of nuclear factor-κB (RANK) with its ligand RANKL activates the main signaling pathway for osteoclastogenesis. However, compelling evidence indicates that this pathway may not be sufficient for the production of mature osteoclast cells and that co-stimulatory signals may be required for both the expression of osteoclast-specific genes and the activation of osteoclasts. Osteoclast-associated receptor (OSCAR), a regulator of osteoclast differentiation, provides one such co-stimulatory pathway. This review summarizes our present knowledge of osteoclastogenesis signaling and the role of OSCAR in the normal production of bone-resorbing cells and in bone disease. Understanding the signaling mechanism through this receptor and how it contributes to the production of mature osteoclasts may offer a more specific and targeted approach for pharmacological intervention against pathological bone resorption. |
| Databáze: | OpenAIRE |
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