Disappearance of monosomy 7 in a patient with aplastic anemia after eltrombopag treatment

Autor:	Yoshimasa Kamoda, Michiko Kida, Masako Hirao, Hiromitsu Iizuka, Yusuke Uchibori, Kensuke Usuki, Akira Hangaishi
Rok vydání:	2020
Předmět:	medicine.medical_specialty Darbepoetin alfa Eltrombopag Benzoates Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Humans Aplastic anemia Aged Danazol medicine.diagnostic_test business.industry Myelodysplastic syndromes Anemia Aplastic Hematology medicine.disease Pancytopenia Bone marrow examination Hydrazines Hypomethylating agent chemistry 030220 oncology & carcinogenesis Pyrazoles Female Chromosome Deletion business Chromosomes Human Pair 7 030215 immunology medicine.drug
Zdroj:	Hematology. 25:165-167
ISSN:	1607-8454
Popis:	We present the case of a patient with aplastic anemia (AA) who was treated with eltrombopag. To the best of our knowledge, this is the first report of the disappearance of monosomy 7 after eltrombopag treatment. The patient was a 77-year-old woman with intraoral hematoma and purpura who was diagnosed with very severe AA with a normal karyotype. After combination therapy with rabbit antithymocyte globulin, cyclosporin, and granulocyte-colony-stimulating factor (G-CSF), pancytopenia transiently improved. When pancytopenia worsened again, the patient was administered darbepoetin alfa for renal anemia and danazol. Bone marrow examination showed 2.5% blasts with the karyotype 45,XX,-7[17]/46,XX[3], and 87.0% of marrow cells had monosomy 7, as determined by 7q31 interphase fluorescence in situ hybridization (FISH) analysis. Pancytopenia was considered owing to the evolution of myelodysplastic syndrome, and we stopped G-CSF and darbepoetin treatment. As she refused treatment with a hypomethylating agent, considering her age, eltrombopag was started against refractory pancytopenia after obtaining informed consent. She showed an improvement in pancytopenia and became transfusion independent. After 1 year of eltrombopag treatment, bone marrow examination revealed 0.7% blasts with the karyotype 46,XX[20] and without monosomy 7 clone by FISH analysis. After a further 1 year of eltrombopag treatment with dose tapering, she has achieved a complete response. This case suggested that eltrombopag treatment is not necessarily contraindicated in patients with monosomy 7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a8cd1ebf863e4b3b6b4f56b097a9b4 https://doi.org/10.1080/16078454.2020.1757331 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.