Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach
| Autor: | Mariana F. Fernández, Nicolás Olea, Piedad Martin-Olmedo, Beatriz González-Alzaga, Vicente Mustieles, Andrés Fontalba-Navas, Juan P. Arrebola, Russ Hauser |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Longitudinal study Type 2 diabetes 010501 environmental sciences 01 natural sciences Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Hydrocarbons Chlorinated medicine Humans Longitudinal Studies 030212 general & internal medicine lcsh:Environmental sciences Aged Dyslipidemias 0105 earth and related environmental sciences General Environmental Science Metabolic Syndrome lcsh:GE1-350 business.industry Proportional hazards model Hypertriglyceridemia Confounding Environmental Exposure Middle Aged medicine.disease Obesity Cross-Sectional Studies Endocrinology Adipose Tissue Diabetes Mellitus Type 2 Spain Hypertension Cohort Environmental Pollutants Female Metabolic syndrome business |
| Zdroj: | Environment International, Vol 104, Iss, Pp 48-57 (2017) |
| ISSN: | 0160-4120 |
| Popis: | We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome (“metabolically compromised”) was defined as having ≥1 diagnosis of type 2 diabetes, hypertension, hypertriglyceridemia, and/or low HDL cholesterol. The cross-sectional analysis was conducted in the initial cohort, while the 10-year longitudinal analysis was conducted in those 154 participants free of any of the so-mentioned metabolic diseases and classified as “metabolically healthy” at recruitment. Statistical analyses were performed using single and multi-pollutant approaches through logistic and Cox regression analyses with elastic net penalty. After adjusting for confounders, β-hexachlorocyclohexane (β-HCH) and hexachlorobenzene (HCB) were independently associated with an increased risk of being metabolically compromised (unpenalized ORs=1.17, 95% CI=1.01–1.36 and 1.17, 95% CI=0.99–1.38, respectively). Very similar results were found in the 10-year longitudinal analysis [HRs=1.28, 95% CI=1.01–1.61 (β-HCH); 1.26, 95% CI=1.00–1.59 (HCB)] and were in line with those obtained using elastic net regression. Finally, when the arithmetic sum of both compounds was used as independent variable, risk estimates increased to OR=1.25, 95% CI=1.03–1.52 and HR=1.32, 95% CI=1.02–1.70. Our results suggest that historical exposure to HCB and β-HCH is consistently associated with the risk of metabolic disorders, and that these POPs might be partly responsible for the morbidity risk traditionally attributed to age and obesity. Keywords: Metabolic syndrome, Metabolic disruption, Persistent organic pollutants, Organochlorine pesticides, Polychlorinated biphenyls |
| Databáze: | OpenAIRE |
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