Effects of Weekly Iron and Folic Acid Supplements on Malaria Risk in Nulliparous Women in Burkina Faso: A Periconceptional, Double-Blind, Randomized Controlled Noninferiority Trial
| Autor: | Brian Faragher, Halidou Tinto, Dorine W. Swinkels, Sabine Gies, Salou Diallo, Yves Claeys, Adama Kazienga, Bernard J. Brabin, Sayouba Ouedraogo, Matthew Powney, Anneke Geurts-Moespot, Stephen A Roberts, Umberto D'Alessandro, Loretta Brabin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Nonpregnant
Parasitemia Pregnant Adolescents law.invention 0302 clinical medicine Randomized controlled trial law Pregnancy Immunology and Allergy qu_188 qu_220 030212 general & internal medicine adolescents 2. Zero hunger wa_30 Obstetrics Anemia Iron deficiency 3. Good health Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] Infectious Diseases Female wa_309 nonpregnant medicine.medical_specialty Adolescent Iron malaria World Health Organization 03 medical and health sciences Major Articles and Brief Reports Folic Acid All institutes and research themes of the Radboud University Medical Center pregnant parasitic diseases medicine Humans Parasites business.industry medicine.disease Malaria wc_750 Clinical trial Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] Relative risk Dietary Supplements business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Infectious Diseases, 218, 7, pp. 1099-1109 The Journal of Infectious Diseases, 218, 1099-1109 The Journal of Infectious Diseases Gies, S, Diallo, S, Roberts, S A, Kazienga, A, Powney, M, Brabin, L, Ouedraogo, S, Swinkels, D W, Geurts-Moespot, A J, Claeys, Y, D'Alessandro, U, Tinto, H, Faragher, B & Brabin, B 2018, ' Effects of weekly iron and folic acid supplements on malaria risk in nulliparous women in Burkina Faso : A periconceptional, double-blind, randomized controlled noninferiority trial ', Journal of INfectious Diseases, vol. 218, no. 7, pp. 1099-1109 . https://doi.org/10.1093/infdis/jiy257 |
| ISSN: | 0022-1899 |
| DOI: | 10.1093/infdis/jiy257 |
| Popis: | Weekly iron supplementation, given to young nulliparous women living in a malaria-endemic area, neither improved iron status nor increased malaria risk, suggesting that current iron recommendations may need revisiting for these women. Background The safety of iron supplementation for young women is uncertain in malaria-endemic settings. Methods This was a double-blind, randomized controlled noninferiority trial in rural Burkina Faso. Results A total of 1959 nulliparae were assigned to weekly supplementation (60 mg iron and 2.8 mg folic acid) (n = 980) or 2.8 mg folic acid (n = 979) until first antenatal visit (ANC1), or 18 months if remaining nonpregnant. Three hundred fifteen women attended ANC1, and 916 remained nonpregnant. There was no difference at ANC1 in parasitemia prevalence (iron, 53.4% [95% confidence interval {CI}, 45.7%–61.0%]; control, 55.3% [95% CI, 47.3%–62.9%]; prevalence ratio, 0.97 [95% CI, .79–1.18]; P = .82), anemia (adjusted effect, 0.96 [95% CI, .83–1.10]; P = .52), iron deficiency (adjusted risk ratio [aRR], 0.84 [95% CI, .46–1.54]; P = .58), or plasma iron biomarkers. Outcomes in nonpregnant women were parasitemia (iron, 42.9% [95% CI, 38.3%–47.5%]; control, 39.2% [95% CI, 34.9%–43.7%]; prevalence ratio, 1.09 [95% CI, .93–1.28]; P = .282); anemia (aRR, 0.90 [95% CI, .78–1.05]; P = .17), and iron deficiency (aRR, 0.99 [95% CI, .77–1.28]; P = .96), with no iron biomarker differences. Conclusions Weekly iron supplementation did not increase malaria risk, improve iron status, or reduce anemia in young, mostly adolescent menstruating women, nor in early pregnancy. World Health Organization Guidelines for universal supplementation for young nulliparous women may need reassessment. Clinical Trials Registration NCT01210040. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|