Implications on Emergence of Antimicrobial Resistance as a Critical Aspect in the Design of Oral Sustained Release Delivery Systems of Antimicrobials
| Autor: | Ehud Horwitz, Amnon Hoffman, Mervyn Shapiro, Ronit Cohen-Poradosu, Shmuel Hess, Anna Edelberg, Lilach Kleinberg |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Drug Time Factors Colon medicine.drug_class Chemistry Pharmaceutical Drug Compounding media_common.quotation_subject Antibiotics Colony Count Microbial Administration Oral Pharmaceutical Science Ileum Pharmacology beta-Lactamases Dosage form Feces Antibiotic resistance Anti-Infective Agents Oral administration Drug Resistance Bacterial Animals Medicine Pharmacology (medical) Intestinal Mucosa Rats Wistar Gastrointestinal Transit Intubation Gastrointestinal media_common business.industry Organic Chemistry Amoxicillin Antimicrobial Rats Intestines medicine.anatomical_structure Intestinal Absorption Delayed-Action Preparations Drug Design Molecular Medicine business Biotechnology medicine.drug |
| Zdroj: | Pharmaceutical Research. 25:667-671 |
| ISSN: | 1573-904X 0724-8741 |
| DOI: | 10.1007/s11095-007-9373-6 |
| Popis: | To assess the effects of the unabsorbed fraction of an orally administered antimicrobial drug which enters the colon on the emergence of resistance among the natural microflora, a phenomenon largely overlooked so far despite its clinical importance, especially when sustained release formulations are used.Effects of an orally administered model beta-lactam antibiotic (amoxicillin) on emergence of resistant bacteria were assessed using a microbiological assay for qualitative and quantitative determination of resistant bacteria in fecal samples of rats following gastric administration of the drug to rats for 4 consecutive days. Time- and site-controlled administration of a beta-lactamase to the rat colon was assessed as a potential strategy for prevention the emergence of resistant bacteria following oral administration of incompletely absorbed antimicrobials.Emergence of resistant bacteria was demonstrated following oral administration of amoxicillin to rats, whereas de-activation of the beta-lactam prior to entering the colon, by infusion of a beta-lactamase into the lower ileum, was shown to prevent the emergence of resistant colonic bacteria.This study illustrates the need to consider the emergence of antimicrobial resistance as a goal equally important to microbiological and clinical cure, when designing oral sustained-release delivery systems of antimicrobial drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink