Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
| Autor: | Fabiola Mejia Rodriguez, Josefina Romero Rendon, Anita O' Connor, Paola Medina, Xinhua Liu, Daniela Hinojosa, M Veronica Ponce Castañeda, Silvia Bhatt Carreño, Ambar Ruiz, Lourdes Cabrera-Muñoz, Laura Rodriguez, Hector Pinilla, Marco A Ramirez Ortiz, Manuela Orjuela-Grimm, Norma Citlali Lara Molina |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Eye Diseases elevation Retinal Neoplasms Mothers Physiology Disease retinoblastoma Young Adult chemistry.chemical_compound sun exposure Risk Factors Epidemiology medicine Vitamin D and neurology Humans RC254-282 Sunlight Sporadic Retinoblastoma business.industry Retinoblastoma Incidence (epidemiology) Infant Neoplasms. Tumors. Oncology. Including cancer and carcinogens Retinal Prognosis medicine.disease eye diseases Oncology chemistry Case-Control Studies Female Original Article epidemiology intraocular disease business protective Follow-Up Studies |
| Zdroj: | Cancer Reports, Vol 4, Iss 6, Pp n/a-n/a (2021) Cancer Reports |
| ISSN: | 2573-8348 |
| Popis: | Background Prior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence. Aims Our study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of sporadic disease) and the risk of retinoblastoma, and (2) to examine the relationship between sun exposure during postnatal retinal development, and the extent of disease among children with unilateral and bilateral retinoblastoma. Methods and results We interviewed 511 mothers in the EpiRbMx case‐control study about their child's exposure to sunlight during postnatal retinal cell division by examining three time periods prior to Rtb diagnosis coinciding with developmental stages in which outdoor activities vary. Weekly sun exposure was compared by age period, between unilateral (n = 259), bilateral (n = 120), and control (n = 132) children, accounting for two factors affecting UV exposure: residential elevation and reported use of coverings to shield eyes. For cases, association between sunlight exposure and clinical stage was examined by laterality at each age period. After adjusting for maternal education and elevation, sun exposure was lower in cases than controls in all three age periods especially during the first 6 months, and in children 12–23 months whose mothers did not cover their eyes when outdoors. In children diagnosed after 12 months of age, sun exposure during the second year of life (age 12–23 months) appeared inversely correlated (r = −0.25) with more advanced intraocular disease in bilateral Rtb children after adjusting for maternal education, residential elevation, and age of diagnosis (p |
| Databáze: | OpenAIRE |
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