Interaction between FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages
| Autor: | Ming Q, Xiao-Li Tian, Yi Zeng, Xiaomin Liu, Ting Ni, Michael W. Lutz, Qihua Tan, Lei Feng, Jianxin Li, Li Y, Jiehua Lu, James W. Vaupel, Yang Z, Chao Nie, Willcox Dc, Elizabeth R. Hauser, Bradley J. Willcox, William K. Gottschalk, Lars Bolund, Simon G. Gregory, Huashuai Chen, Wei Tao, Junxia Min, Anatoli I. Yashin, Jun Gu, Rongping Ruan, Kenneth C. Land, Huanming Yang, Zhang F |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine China Heterozygote Aging Genotype Biology Lower risk Risk Assessment 03 medical and health sciences longevity Gene Frequency Risk Factors Cause of Death Aging/genetics Humans Gene–environment interaction Allele frequency Survival analysis Aged 80 and over Genetics Forkhead Box Protein O1/genetics Forkhead Box Protein O1 Proportional hazards model Homozygote Age Factors Gene targeting Original Articles Protective Factors mortality Survival Analysis Minor allele frequency Phenotype 030104 developmental biology Female Gene-Environment Interaction Geriatrics and Gerontology diet Risk assessment Demography |
| Zdroj: | Zeng, Y, Chen, H, Ni, T, Ruan, R, Nie, C, Liu, X, Feng, L, Zhang, F, Lu, J, Li, J, Li, Y, Tao, W, Gottschalk, W, Lutz, M, Land, K, Yashin, A I, Tan, Q, Yang, Z, Bolund, L, Qi, M, Yang, H, Min, J, Willcox, C D, Willcox, B, Gu, J, Hauser, E, Tian, X-L & Vaupel, J W 2016, ' Interaction between FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages ', Rejuvenation Research, vol. 19, no. 3, pp. 195-203 . https://doi.org/10.1089/rej.2015.1737 Zeng, Y, Chen, H, Ni, T, Ruan, R, Nie, C, Liu, X, Feng, L, Zhang, F, Lu, J, Li, J, Li, Y, Tao, W, Gregory, S G, Gottschalk, W, Lutz, M, Land, K, Yashin, A I, Tan, Q, Yang, Z, Bolund, L, Qi, M, Yang, H, Min, J, Willcox, C D, Willcox, B, Gu, J, Hauser, E, Tian, X-L & Vaupel, J W 2016, ' Interaction between the FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages ', Rejuvenation Research, vol. 19, no. 3, pp. 195-203 . https://doi.org/10.1089/rej.2015.1737 |
| DOI: | 10.1089/rej.2015.1737 |
| Popis: | On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are significantly associated with lower risk of mortality at advanced ages. Such a significant association is replicated in two independent Han Chinese CLHLS cohorts (p = 0.028-0.048 in the discovery and replication cohorts, and p = 0.003-0.016 in the combined dataset). We found the associations between tea drinking and reduced mortality are much stronger among carriers of the FOXO1A-209 genotype compared to non-carriers, and drinking tea is associated with a reversal of the negative effects of carrying FOXO1A-209 minor alleles, that is, from a substantially increased mortality risk to substantially reduced mortality risk at advanced ages. The impacts are considerably stronger among those who carry two copies of the FOXO1A minor allele than those who carry one copy. On the basis of previously reported experiments on human cell models concerning FOXO1A-by-tea-compounds interactions, we speculate that results in the present study indicate that tea drinking may inhibit FOXO1A-209 gene expression and its biological functions, which reduces the negative impacts of FOXO1A-209 gene on longevity (as reported in the literature) and offers protection against mortality risk at oldest-old ages. Our empirical findings imply that the health outcomes of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles, and the research on the effects of nutrigenomics interactions could potentially be useful for rejuvenation therapies in the clinic or associated healthy aging intervention programs. |
| Databáze: | OpenAIRE |
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