Direct Synthesis of Radioactive Gold Nanoparticles Using a Research Nuclear Reactor
| Autor: | Carlos Henry Castano Giraldo, Joshua P. Schlegel, Maria C. Garcia Toro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Radiochemistry
Materials science Radiological and Ultrasound Technology Polyvinylpyrrolidone Metal Nanoparticles Nanoparticle 02 engineering and technology General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Nanomaterials Nuclear Reactors Colloidal gold Neutron flux Transmission electron microscopy medicine Radiology Nuclear Medicine and imaging Gold Irradiation Particle size 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Nuclear Medicine Technology. 46:280-284 |
| ISSN: | 1535-5675 0091-4916 |
| Popis: | We report the single-step synthesis of radioactive gold nanoparticles with an activity and size appropriate for potential use in cancer treatment and diagnosis. Methods: A solution of 2 mM gold chloride (HAuCl4⋅3H2O), 1 mM polyvinylpyrrolidone (molecular weight, 360,000), and 60 mM 2-propanol was prepared in deionized water. Seven different samples of the solution were irradiated in a neutron flux of 7.45 × 1012 n/cm2⋅s in a research reactor for 0.5, 1, 3, 5, 10, 30, or 60 min. The resulting nanoparticles were characterized for morphology and chemical composition using a transmission electron microscope and ImageJ. Results: The obtained nanoparticles were 3–450 nm in size. The average size depended on the length of irradiation, with a longer irradiation producing smaller nanoparticles. Irradiation for 10 min produced nanoparticles with characteristics suitable for potential cancer treatment and diagnosis (average size, 50 nm; activity, 6.85 MBq/mL). Conclusion: Direct production of chemically stable radioactive gold nanoparticles was successfully accomplished using the Missouri University of Science and Technology reactor. The nanoparticles had physical and radioactive characteristics potentially useful for cancer treatment and diagnosis. |
| Databáze: | OpenAIRE |
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