Eosinophils participate in modulation of liver immune response and tissue damage induced by Schistosoma mansoni infection in mice
| Autor: | Vinícius Gustavo de Oliveira, Deborah Negrão-Corrêa, Vanessa Fernandes Rodrigues, João Marcelo Peixoto Moreira, Laura Maggi, Jailza Lima Rodrigues, Samira Diniz Resende |
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| Rok vydání: | 2021 |
| Předmět: |
Immunology
Schistosomiasis Biochemistry Parasite load Mice Immune system Antigen Fibrosis medicine Immunology and Allergy Animals Molecular Biology Eosinophil differentiation Mice Inbred BALB C Granuloma biology Liver Diseases Immunity Neglected Diseases Hematology biology.organism_classification medicine.disease Schistosomiasis mansoni Eosinophils Intestines Disease Models Animal Liver Cytokines Female Schistosoma mansoni |
| Zdroj: | Cytokine. 149 |
| ISSN: | 1096-0023 |
| Popis: | The severity of chronic schistosomiasis has been mainly associated with the intensity and extension of the inflammatory response induced by egg-secreted antigens in the host tissue, especially in the liver and intestine. During acute schistosomiasis, eosinophils account for approximately 50% of the cells that compose the liver granulomas; however, the role of this cell-type in the pathology of schistosomiasis remains controversial. In the current study, we compared the parasite burden and liver immunopathological changes during experimental schistosomiasis in wild-type (WT) BALB/c mice and BALB/c mice selectively deficient for the differentiation of eosinophils (ΔdblGATA). Our data demonstrated that the absence of eosinophil differentiation did not alter the S. mansoni load or the liver retention of parasite eggs; however, there were significant changes in the liver immune response profile and tissue damage. S. mansoni infection in ΔdblGATA mice resulted in significantly lower liver concentrations of IL-5, IL-13, IL-33, IL-17, IL-10, and TGF-β and higher concentrations of IFN-γ and TNF-α, as compared to WT mice. The changes in liver immune response observed in infected ΔdblGATA mice were accompanied by lower collagen deposition, but higher liver damage and larger granulomas. Moreover, the absence of eosinophils resulted in a higher mortality rate in mice infected with a high parasite load. Therefore, the data indicated that eosinophils participate in the establishment and/or amplification of liver Th-2 and regulatory response induced by S. mansoni, which is necessary for the balance between liver damage and fibrosis, which in turn is essential for modulating disease severity. |
| Databáze: | OpenAIRE |
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