Primary Gastrointestinal Non-Hodgkin’s Lymphoma: I. Anatomic and Histologic Distribution, Clinical Features, and Survival Data of 371 Patients Registered in the German Multicenter Study GIT NHL 01/92
| Autor: | Jürgen Schultze, Achim Heinecke, Bernward Grothaus-Pinke, Arved Junker, Altfried Temmesfeld, Andreas Probst, Christiane Pott, Rudolf Schmitz, Peter Koch, Normann Willich, Berthold Reers, Wolfgang Hiddemann, R. Parwaresch, Heinrich Bodenstein, C. Rübe, Wolfgang E. Berdel, Jens Brockmann, Gabriele Reinartz, M. Tiemann, Francisco del Valle, Gert Jaenke |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Pathology Adolescent medicine.medical_treatment Gastroenterology Survival data immune system diseases Germany hemic and lymphatic diseases Internal medicine medicine Humans In patient Prospective Studies Registries Grading (tumors) Aged Gastrointestinal Neoplasms Neoplasm Staging Aged 80 and over Primary Gastrointestinal Non-Hodgkin's Lymphoma Chemotherapy business.industry Lymphoma Non-Hodgkin Middle Aged Survival Analysis Radiation therapy Oncology Multicenter study Histopathology business |
| Zdroj: | Journal of Clinical Oncology. 19:3861-3873 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2001.19.18.3861 |
| Popis: | PURPOSE: The study was initiated to obtain epidemiologic data and information on anatomic and histologic distribution, clinical features, and treatment results in patients with primary gastrointestinal non-Hodgkin’s lymphomas (PGI NHL). PATIENTS AND METHODS: Between October 1992 and November 1996, 371 PGI NHL patients were eligible to evaluate clinical features. Radiotherapy and chemotherapy were stratified according to histologic grading, stage, and whether surgery had been carried out or not. RESULTS: A total of 74.8% patients had gastric NHL (PGL). Within the intestine, the small bowel and the ileocecal region were involved in 8.6% and 7.0% of the cases, respectively. Multiple GI involvement (MGI) was 6.5%. Approximately 90% of the GI NHL were in stages IE/IIE. Aggressive NHL accounted for the majority, with a distinguishable pattern in several sites. Forty percent of PGL were of low-grade mucosa-associated lymphatic tissue type. One third of large-cell lymphomas had low-grade components. Most intestinal NHL were germinal-center lymphomas. The site of origin was prognostic. In gastric and ileocecal lymphoma, event-free (EFS) and overall survival (OS) were significantly higher as compared with the small intestine or MGI (median time of observation, 51 months). In PGL, localized disease was prognostic for EFS and OS. Histologic grade influenced only EFS significantly. Numbers in intestinal lymphomas were too small for subanalyses. CONCLUSION: PGI NHL are heterogeneous diseases. The number of localized PGL allowed for detailed analyses. Larger studies are needed for stages III and IV and for intestinal NHL. A uniform reporting system for PGI NHL, in terms of definitions and histologic and staging classifications, is needed to facilitate comparison of treatment results. |
| Databáze: | OpenAIRE |
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