Indoleamine 2,3-Dioxygenase Is Involved in Defense againstNeospora caninumin Human and Bovine Cells
| Autor: | Walter Däubener, Kathrin Heseler, V. Ince, Markus Czesla, Gereon Schares, Silvia K. Schmidt, K. Spekker |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_treatment
Immunology Microbiology Cell Line Neospora Immune system parasitic diseases medicine Animals Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Interferon gamma Indoleamine 2 3-dioxygenase biology Intracellular parasite fungi Endothelial Cells Toxoplasma gondii Epithelial Cells Fibroblasts biology.organism_classification Virology Neospora caninum Infectious Diseases Cytokine Cattle Parasitology Fungal and Parasitic Infections medicine.drug |
| Zdroj: | Infection and Immunity. 77:4496-4501 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00310-09 |
| Popis: | Neospora caninumis an apicomplexan parasite closely related toToxoplasma gondii. In nature this parasite is found especially in dogs and cattle, but it may also infect other livestock. The growth ofN. caninum, which is an obligate intracellular parasite, is controlled mainly by the cell-mediated immune response. During infection the cytokine gamma interferon (IFN-γ) plays a prominent role in regulating the growth ofN. caninumin natural and experimental disease. The present study showed that induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) is responsible for the inhibition of parasite growth that is mediated by IFN-γ-activated bovine fibroblasts and endothelial cells. This antiparasite effect could be abrogated by addition of tryptophan, as well as by the IDO-specific inhibitor 1-l-methyltryptophan. In conclusion, our data show that human and bovine cells use the same effector mechanism to control the growth ofN. caninum. |
| Databáze: | OpenAIRE |
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