Decreased point prevalence of Haemophilus influenzae type b (Hib) oropharyngeal colonization by mass immunization of Brazilian children less than 5 years old with hib polyribosylribitol phosphate polysaccharide-tetanus toxoid conjugate vaccine in combination with diphtheria-tetanus toxoids-pertussis vaccine
| Autor: | C. F. de Oliveira, I. M. Mimica, L. M. J. Mimica, Rosemeire Cobo Zanella, E. M. C. P. Maluf, Brandileone Mc, V. S. D. Vieira, E. Forleo-Neto, J. M. R. Araujo, L. F. Kunz, C. Bataglin, A. K. Pustai |
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| Přispěvatelé: | Pasteur Merieux Connaught Brasil, Universidade Federal de São Paulo (UNIFESP), Secretaria Estado Saude São Paulo, Santa Casa Misericordia São Paulo, Secretaria Municipal Saude Curitiba, Secretaria Municipal Saude Porto Alegre |
| Rok vydání: | 1999 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Oropharynx Booster dose medicine.disease_cause complex mixtures Haemophilus influenzae Conjugate vaccine medicine Ethnicity Tetanus Toxoid Immunology and Allergy Humans Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines Vaccines Conjugate business.industry Tetanus Diphtheria Toxoid Infant Child Day Care Centers medicine.disease Vaccination Infectious Diseases Child Preschool Immunology Carrier State Housing Pertussis vaccine Female business Brazil medicine.drug |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 0022-1899 |
| Popis: | A protective herd effect has been described after susceptible populations of children are vaccinated with conjugate Haemophilus influenzae type b (Hib), Hib carriage was studied in children aged 6-24 months attending day care centers in two cities in southern Brazil (Curitiba and Porto Alegre), in Curitiba, routine immunization with Hib polyribosylribitol phosphate polysaccharide-tetanus toroid conjugate vaccine (PRP-T) in combination with diphtheria-tetanus toxoids-pertussis vaccine (PRP-T/DTP) has been offered since September 1996; DTP vaccine alone is routinely given in Porto Alegre, Children in Porto Alegre (n = 643) were 8 times less likely to have received adequate Hib vaccination and 4 times more likely to be Hib carriers than children in Curitiba (n = 647; i.e., point prevalence of oropharyngeal colonization, 4.8% vs. 1.2%). Point prevalence of carriage with non-type b or other nontypeable Hi was similar in children of both cities, There was a vaccination effect on carriage rates in children who received a primary 3-dose series, independent of the booster dose, suggesting that a booster may be unnecessary to induce population protection. Pasteur Merieux Connaught Brasil, Dept Med, BR-04552905 São Paulo, Brazil Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil Secretaria Estado Saude São Paulo, Inst Adolfo Lutz, Seccao Bacteriol, São Paulo, Brazil Santa Casa Misericordia São Paulo, Fac Ciencias Med, Dept Patol, São Paulo, Brazil Secretaria Municipal Saude Curitiba, Dept Epidemiol, Curitiba, Parana, Brazil Secretaria Municipal Saude Porto Alegre, Dept Epidemiol, Porto Alegre, RS, Brazil Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil Web of Science |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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