Pancreatic Islet Transplantation Technologies: State of the Art of Micro- and Macro-Encapsulation
| Autor: | Lorenzo Piemonti, Elisa Cantarelli, Antonio Citro |
|---|---|
| Přispěvatelé: | Cantarelli, Elisa, Citro, Antonio, Piemonti, Lorenzo |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Immunology 02 engineering and technology 03 medical and health sciences Cell transplantation medicine Intensive care medicine Transplantation geography geography.geographical_feature_category Hepatology business.industry Pancreatic islets Immunosuppression 021001 nanoscience & nanotechnology Islet Biocompatible material 030104 developmental biology medicine.anatomical_structure Nephrology Surgery Pancreatic islet transplantation Immune reaction 0210 nano-technology business |
| Zdroj: | Current Transplantation Reports. 4:169-183 |
| ISSN: | 2196-3029 |
| DOI: | 10.1007/s40472-017-0154-9 |
| Popis: | Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of insulin-producing cells in pancreatic islets. Despite islet transplantation is effective for selected T1D patients, its widespread application is limited by islet donor shortage and the need for lifelong immunosuppression. Micro- and macro-encapsulation aimed at enveloping cells in a perm-selective biocompatible membrane can potentially eliminate these limitations. This review summarizes tissue-engineering approaches tested in preclinical models of islet transplantation, highlighting technologies currently in the clinic. More than 40 years of intensive research raised promises and challenges. Ongoing clinical studies have not yet achieved the desired success as obstacles remained to be overcome: deleterious fibrotic response toward the biomaterial, poor vascularization, insufficient oxygen delivery, and recipient’s immune reaction. Only the joint effort of bioengineering, cell biology, and immunology expertises will foster the development of novel, effective, and safe technologies for insulin-producing cell transplantation. |
| Databáze: | OpenAIRE |
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