Quantifying cortical bone free water using short echo time (STE-MRI) at 1.5 T

Autor: Atena Akbari, Hossein Arabalibeik, Mohamad Shahgholi, Hamidreza Saligheh Rad, Malakeh Malekzadeh, Shahrokh Abbasi-Rad
Rok vydání: 2020
Předmět:
Adult
Male
Population
Biomedical Engineering
Biophysics
FOS: Physical sciences
030218 nuclear medicine & medical imaging
03 medical and health sciences
Young Adult
0302 clinical medicine
Healthy volunteers
FOS: Electrical engineering
electronic engineering
information engineering
medicine
Cortical Bone
Animals
Humans
Radiology
Nuclear Medicine and imaging
education
Reproducibility
education.field_of_study
medicine.diagnostic_test
Human studies
business.industry
Image and Video Processing (eess.IV)
Reproducibility of Results
Water
Magnetic resonance imaging
Electrical Engineering and Systems Science - Image and Video Processing
Middle Aged
Physics - Medical Physics
Magnetic Resonance Imaging
Healthy Volunteers
medicine.anatomical_structure
Cross-Sectional Studies
Free water
Cortical bone
Cattle
Female
Medical Physics (physics.med-ph)
Nuclear medicine
business
030217 neurology & neurosurgery
Short echo time
Zdroj: Magnetic resonance imaging. 71
ISSN: 1873-5894
Popis: Purpose The purpose of our study was to use Dual-TR STE-MR protocol as a clinical tool for cortical bone free water quantification at 1.5 T and validate it by comparing the obtained results (MR-derived results) with dehydration results. Methods Human studies were compliant with HIPPA and were approved by the institutional review board. Short Echo Time (STE) MR imaging with different Repetition Times (TRs) was used for quantification of cortical bone free water T1 (T1free) and concentration (ρfree). The proposed strategy was compared with the dehydration technique in seven bovine cortical bone samples. The agreement between the two methods was quantified by using Bland and Altman analysis. Then we applied the technique on a cross-sectional population of thirty healthy volunteers (18F/12M) and examined the association of the biomarkers with age. Results The mean values of ρfree for bovine cortical bone specimens were quantified as 4.37% and 5.34% by using STE-MR and dehydration techniques, respectively. The Bland and Altman analysis showed good agreement between the two methods along with the suggestion of 0.99% bias between them. Strong correlations were also reported between ρfree (r2 = 0.62) and T1free and age (r2 = 0.8). The reproducibility of the method, evaluated in eight subjects, yielded an intra-class correlation of 0.95. Conclusion STE-MR imaging with dual-TR strategy is a clinical solution for quantifying cortical bone ρfree and T1free.
Databáze: OpenAIRE
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