Effects of MK-771 on the isolated amphibian spinal cord: Comparison with thyrotropin-releasing hormone
| Autor: | D. K. Singh, G. G. Yarbrough |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Agonist
endocrine system medicine.medical_specialty Pituitary gland endocrine system diseases Physiology medicine.drug_class Central nervous system Thyrotropin-releasing hormone In Vitro Techniques Biology Membrane Potentials In vivo Physiology (medical) Internal medicine medicine Animals Receptor Thyrotropin-Releasing Hormone Pharmacology Dipeptides General Medicine Spinal cord Bufonidae Thiazoles medicine.anatomical_structure Endocrinology Spinal Cord Thiazolidines hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 57:920-922 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y79-141 |
| Popis: | Topically applied MK-771 (pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide), a novel thyrotropin-releasing hormone (TRH) analog, was found to be equipotent with TRH in depolarizing the ventral roots of the isolated, hemisected amphibian (Bufo marinus) spinal cord. The 3-methyl-histidyl analog of TRH was approximately 10 times more potent than MK-771 and TRH. MK-771 is known to be equiactive with TRH in their actions on the pituitary gland. Taken together these findings suggest that the previously observed enhanced potency of systemically administered MK-771 over TRH in in vivo central nervous system (CNS) test paradigms is not likely to be due to a difference in the agonist requirements of CNS as compared with pituitary receptors for TRH. |
| Databáze: | OpenAIRE |
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