Functionalized nerve conduits for peripheral nerve regeneration: A literature review
| Autor: | I. Pluvy, Gauthier Menu, Laurent Obert, Inès Regas, François Loisel, Harrison Haight |
|---|---|
| Přispěvatelé: | INSERM Centre Innovation Technologique 808 (INSERM CIT 808), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Nanomédecine, imagerie, thérapeutique - UFC (EA 4662) (NIT / NANOMEDECINE), Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) (NIT / NANOMEDECINE), CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell Transplantation
[SDV]Life Sciences [q-bio] 030230 surgery Extracellular matrix 03 medical and health sciences 0302 clinical medicine Tissue engineering Neurotrophic factors Peripheral nerve Absorbable Implants medicine Animals Humans Orthopedics and Sports Medicine Nerve Growth Factors Peripheral Nerves 030222 orthopedics Tissue Engineering Guided Tissue Regeneration business.industry Regeneration (biology) Rehabilitation Prostheses and Implants Functional recovery Extracellular Matrix [SDV] Life Sciences [q-bio] medicine.anatomical_structure Surgery Stem cell business Biomedical engineering Reinnervation |
| Zdroj: | Hand Surgery and Rehabilitation Hand Surgery and Rehabilitation, Elsevier, 2020, 39, pp.343-351. ⟨10.1016/j.hansur.2020.05.007⟩ |
| ISSN: | 2468-1229 2468-1210 |
| DOI: | 10.1016/j.hansur.2020.05.007⟩ |
| Popis: | Functionalized neurotube are a third-generation of conduits with chemical or architectural bioactivity developed for axonal proliferation. The goal of this review is to provide a synopsis of the functionalized nerve conduits described in the literature according to their chemical and architectural properties and answer two questions: what are their mechanisms of action? Has their efficacy been proven compared to the autologous nerve graft? Our literature review relates all kind of conduits corresponding to functionalized neurotubes in peripheral nerve regeneration found in Medline and PubMed Central. Studies developing nerve gaps, chemotactic or structural features promoting each conduit, results, efficiency were selected. Fifty-five studies were selected and classified in: (a) intraluminal neurotrophic factors; (b) cell-based therapy (combined-in-vein muscles, amniotic membrane, Schwann cells, stem cells); (c) extracellular matrix proteins; (d) tissue engineering; (e) bioimplants. Functionalized neurotubes showed significantly better functional results than after end-to-end nerve suture. No studies can be able to show that neurotube results were better than autologous nerve graft results. We included all studies regardless of effectives to evaluate quality of reinnervation with modern tubulization. Functionalized neurotubes promote basic conduits for peripheral nerve regeneration. Thanks to bioengineering and microsurgery improvement, further neurotubes could promote best level of regeneration and functional recovery to successfully bridge a critical nerve gap. |
| Databáze: | OpenAIRE |
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