| Autor: |
Heather Friberg, Morgan Gargulak, Amanda Kong, Leyi Lin, Luis J. Martinez, Alexander C. Schmidt, Robert M. Paris, Richard G. Jarman, Clemente Diaz, Stephen J. Thomas, Philippe Moris, Jeffrey R. Currier |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
NPJ vaccines. 7(1) |
| ISSN: |
2059-0105 |
| Popis: |
The increasing global impact of dengue underscores the need for a dengue virus (DENV) vaccine. We assessed B-cell and T-cell responses following vaccination with four formulations of a tetravalent dengue purified inactivated vaccine (DPIV) in dengue-primed and dengue-naive adults from two studies (NCT01666652, NCT01702857). Frequencies of DPIV-induced memory B cells specific to each DENV serotype remained high up to 12 months post-vaccination, and were higher in the dengue-primed than dengue-naive adults. A subsequent DPIV booster dose induced strong anamnestic B-cell responses. Multifunctional CD4+ T cells (predominantly expressing IL-2) were induced by DPIV, with higher frequencies in dengue-primed adults. DPIV-induced CD4+ T cells also demonstrated in vitro proliferative capacity and antigen-specific production of GM-CSF, IFN-γ, and IL-13. CD8+ T-cell responses were undetectable in dengue-naive adults and low in dengue-primed individuals. B- and T-cell responses persisted up to 12 months post-vaccination in both dengue-primed and dengue-naive adults. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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