Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
| Autor: | Jie-Jun Hu, Hai-Tao Gu, Yang Peng, Kang Wang, Fa-Bao Hao, You-Qi-Le Wu, Guo-Chao Zhong, Lun Wan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Population Diet Surveys Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology Humans Multicenter Studies as Topic Medicine Magnesium Prospective Studies Prospective cohort study education Early Detection of Cancer Aged Randomized Controlled Trials as Topic education.field_of_study business.industry Proportional hazards model Incidence Incidence (epidemiology) Liver Neoplasms Hazard ratio Feeding Behavior Middle Aged Survival Analysis Confidence interval Oncology 030220 oncology & carcinogenesis Dietary Supplements Cohort Female business Magnesium Deficiency Follow-Up Studies |
| Zdroj: | International Journal of Cancer. 147:1577-1586 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.32939 |
| Popis: | Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate subdistribution hazard ratios for PLC mortality. Restricted cubic spline regression was employed to test nonlinearity. We documented 116 PLC cases during 1,193,513.5 person-years of follow-up and 100 PLC deaths during 1,198,021.3 person-years of follow-up. Total (diet + supplements) magnesium intake was found to be inversely associated with risks of PLC incidence (hazard ratiotertile 3 vs. 1 : 0.44; 95% confidence interval: 0.24, 0.80; ptrend = 0.0065) and mortality (subdistribution hazard ratiotertile 3 vs. 1 : 0.37; 95% confidence interval: 0.19, 0.71; ptrend = 0.0008). Similar results were obtained for dietary magnesium intake. Nonlinear inverse dose-response associations with PLC incidence and mortality were observed for both total and dietary magnesium intakes (all pnonlinearity |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text