A regulatory role of interleukin 15 in wound healing and mucosal infection in mice
| Autor: | Takahiro Ishikawa, Yukihiro Nishiyama, Yoshiko Kagimoto, Masutaka Furue, Fumi Goshima, Naoyoshi Maeda, Hisakata Yamada, Yasunobu Yoshikai |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Transgene
Herpesvirus 2 Human T-Lymphocytes Immunology Inflammation Mice Transgenic Biology Interferon-gamma Mice Immunity Transforming Growth Factor beta medicine Immunology and Allergy Animals Interleukin-15 Mice Knockout Wound Healing Herpes Genitalis Mucous Membrane T-cell receptor Histocompatibility Antigens Class I Mucous membrane Cell Biology Mucosal Infection Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Interleukin 15 Cytokines Female medicine.symptom Wound healing |
| Zdroj: | Journal of leukocyte biology. 83(1) |
| ISSN: | 0741-5400 |
| Popis: | IL-15 plays a critical role in the development and maturation of γδ intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-β1 upon TCR triggering than in control mice. In vivo neutralization of TGF-β ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-β1, promoting wound healing but impeding protection against genital HSV-2 infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text