RGDS glycosylated peptides as inhibitors of cell-attachment and platelet aggregation
| Autor: | V. Biberovic, Mustapha Si-Tahar, S. Dufour, E. Harth-Fritschy, Michel Chignard, Danièle Cantacuzene |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Platelets
Cell Carbohydrates Fibrinogen Peptides Cyclic Biochemistry Residue (chemistry) Endocrinology Carbohydrate Conformation Cell Adhesion Tumor Cells Cultured medicine Humans Cell adhesion Sugar Molecular Structure biology Chemistry Glycopeptides Biological activity Glycopeptide Fibronectins Fibronectin medicine.anatomical_structure biology.protein Oligopeptides Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | ResearcherID |
| ISSN: | 1397-002X |
| Popis: | Glycopeptides derived from the GRGDS sequence were synthesized to study the effect of the sugar residue on the activity of these peptides. The peptides were tested as inhibitors of cell adhesion to fibronectin and of platelet aggregation. The sugar moiety was found to reduce the biological activity of the parent compounds except for the cyclic derivatives P37 and P38 where the inhibition of platelet aggregation was increased. Some interesting differences were observed between the peptides bearing sugar residues with free hydroxyl groups and those with peracetylated sugars. |
| Databáze: | OpenAIRE |
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