Intrauterine and Lactational Exposure to Paracetamol: Cardiometabolic Evaluation in Adult Female and Male Offspring
| Autor: | Daniela Cristina Ceccatto Gerardin, Camila B. Vidigal, Rodrigo Moreno Klein, Deborah G. da Silva, Graziela S. Ceravolo, Daniella R. B. S. Novi, Ana Flavia L. Serafim, Kawane F. Moura, Estefânia Gastaldello Moreira |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Offspring Physiology Aorta Thoracic Gestational Age Risk Assessment Metabolic Diseases Pregnancy medicine.artery Medicine Thoracic aorta Animals Lactation Rats Wistar Phenylephrine Acetaminophen Adiposity Pharmacology Fetus Adult female business.industry Hemodynamics Analgesics Non-Narcotic Blood pressure Cardiovascular Diseases Prenatal Exposure Delayed Effects Gestation Female Sodium nitroprusside Insulin Resistance Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 78(6) |
| ISSN: | 1533-4023 |
| Popis: | Paracetamol is the most over-the-counter drug recommended by physicians for treatment of pain and fever during gestation. This drug is not teratogenic, being considered safe for fetus, however paracetamol crosses the blood-placental barrier. Considering that, the present study aimed to evaluate the vascular and metabolic safety of paracetamol exposure during intrauterine and neonatal development in adult male and female-exposed offspring. Wistar female rats were gavaged, with paracetamol (PAR - 350mg/kg/day), from gestational day 6 to 21 or from gestational day 6 until postnatal day 21. Control dams received water by gavage at the same periods. The male and female offspring were evaluated at adulthood (80 days of life). The thoracic aorta reactivity to acetylcholine, sodium nitroprusside and phenylephrine was evaluated in male and female adult offspring. It was observed that aortic relaxation was similar between the PAR and control offspring. In addition, the contraction to phenylephrine was similar between the groups. Further, the insulin sensitivity, adipose tissue deposition and blood pressure were not different between PAR and control adult offspring. These results suggest that the protocol of paracetamol exposure used in the present study did not program vascular and metabolic alterations that would contribute to the development of cardiometabolic diseases in adult life, being safe for the exposed offspring. |
| Databáze: | OpenAIRE |
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