Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New?

Autor:	Patrizia Diana, Camilla Pecoraro, Daniela Carbone, Stella Maria Cascioferro, Barbara Parrino
Přispěvatelé:	Pecoraro C., Carbone D., Cascioferro S.M., Parrino B., Diana P.
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Pharmacology Small molecules kinase inhibitors polypharmacology covalent kinase inhibitors allosteric inhibitors Drug Discovery Organic Chemistry Molecular Medicine anticancer drug combinations Biochemistry kinase genetic aberration Settore CHIM/08 - Chimica Farmaceutica
Popis:	The concept of protein kinase inhibition starts from the groundbreaking research on the role of these proteins in the regulation of fundamental processes, including proliferation, cell cycle, apoptosis, metabolism, and inflammation. Kinase genetic mutations, as well as overexpression and dysregulation, can contribute to the development of several diseases, including neoplasms, leading to relapses and resistance to standard drug chemotherapy [1-3].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c4386e26e12b28cba71c1985c092b1 https://hdl.handle.net/10447/580471 Zobrazit plný text záznamu