Targeting the endocannabinoid system with microbial interventions to improve gut integrity
| Autor: | Saskia van Hemert, Fleur Brinkman, Sahar El Aidy, Jack Jansma |
|---|---|
| Přispěvatelé: | Host-Microbe Interactions, Molecular Immunology |
| Rok vydání: | 2020 |
| Předmět: |
Endocannabinoid system
2-Arachidonoylglycerol Gut–brain axis Gut brain axis Inflammation Gut flora Bioinformatics Probiotic Inflammatory bowel disease law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Brain-Gut Axis medicine Animals Humans Gut Intestinal barrier Biological Psychiatry Pharmacology Depressive Disorder Major Gut barrier biology business.industry musculoskeletal neural and ocular physiology Microbiota Probiotics Anandamide medicine.disease biology.organism_classification 030227 psychiatry 2-arachidonoylglycerol Gastrointestinal Microbiome nervous system chemistry lipids (amino acids peptides and proteins) medicine.symptom business psychological phenomena and processes Endocannabinoids |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry, 106:110169. PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 1878-4216 |
| Popis: | The endocannabinoid system is a metabolic pathway involved in the communication between the gut microbiota and the host. In the gut, the endocannabinoid system regulates the integrity of the intestinal barrier. A compromised integrity of the intestinal barrier is associated with several disorders such as inflammatory bowel disorder, obesity and major depressive disorder. Decreasing the integrity of the intestinal barrier results in an increased translocation of bacterial metabolites, including lipopolysaccharides, across the epithelial layer of the gut, causing the subsequent inflammation. Targeting the endocannabinoid system in the gut can improve the integrity of the intestinal barrier. Currently, microbial interventions in the form of probiotics are under investigation for the treatment of diseases related to a compromised integrity of the intestinal barrier. However, the role of the endocannabinoid system in the gut is ambiguous since activity of the endocannabinoid system is increased in obesity and decreased in inflammatory bowel disease, emphasizing the need for development of personalized microbial interventions. This review discusses the role of the endocannabinoid system in regulating the gut barrier integrity and highlights current efforts to develop new endocannabinoid-targeted microbial interventions. |
| Databáze: | OpenAIRE |
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