Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds

Autor:	Ting Han, Cheng-Jian Zheng, Lu-Ping Qin, Khalid Rahman, Qiao-Yan Zhang, Hong Zhang, Bao-Kang Huang
Rok vydání:	2010
Předmět:	Vitex negundo medicine.drug_class Analgesic Anti-Inflammatory Agents Pain Pharmaceutical Science (+)-Naloxone Pharmacology Vitex Mice chemistry.chemical_compound immune system diseases Opioid receptor Drug Discovery medicine Animals Edema Petroleum ether Inflammation Analgesics Mice Inbred ICR Dose-Response Relationship Drug biology Plant Extracts Antagonist General Medicine respiratory system biology.organism_classification respiratory tract diseases Disease Models Animal Dose–response relationship Nociception Solubility Complementary and alternative medicine chemistry Seeds Molecular Medicine Female circulatory and respiratory physiology
Zdroj:	Pharmaceutical Biology. 48:651-658
ISSN:	1744-5116 1388-0209
Popis:	The antinociceptive activities of the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds have been evaluated in several nociceptive mouse models. Given orally, the PEF (at doses of 12, 24, and 48 mg/kg body weight) produced significant dose-related inhibitions on chemical nociception induced by intraperitoneal acetic acid and sub-plantar formalin injections and on thermal nociception in the hot-plate test. Naloxone (1 mg/kg bw subcutaneously), a non-selected opioid receptor antagonist, notably reversed the analgesic effect caused by the PEF (48 mg/kg bw) when assessed against the first phase of the formalin test, but this effect was less significant for the PEF in the second phase. Our observations suggest that the PEF probably interacted with the opioid system and may be more effective on inflammatory pain. In addition, potent anti-inflammatory activity of the PEF was observed in the xylene-induced ear edema test, which further indicates that the analgesic effects of the PEF may be partially mediated by its anti-inflammatory activity. Further chemical analysis suggests that the analgesic activities of the PEF could be mostly due to the abundance of fatty acids with synergetic effects in the present work.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a19f9f097155da880ac8438219a49e https://doi.org/10.3109/13880200903241838 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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