Aspergillus terreus Species Complex
| Autor: | Matthias Brock, Anna-Maria Dietl, Cornelia Lass-Flörl, Dimitrios P. Kontoyiannis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Species complex Antifungal Agents Epidemiology 030106 microbiology Aspergillus Section Fumigati Review Microbial Sensitivity Tests Microbiology Aspergillus fumigatus 03 medical and health sciences Human health Opportunistic pathogen Amphotericin B medicine Aspergillosis Humans Aspergillus terreus skin and connective tissue diseases Aspergillus species General Immunology and Microbiology biology Public Health Environmental and Occupational Health bacterial infections and mycoses biology.organism_classification Aspergillus 030104 developmental biology Infectious Diseases medicine.drug |
| Zdroj: | Clin Microbiol Rev |
| ISSN: | 1098-6618 0893-8512 |
| DOI: | 10.1128/cmr.00311-20 |
| Popis: | Infections due to Aspergillus species are an acute threat to human health; members of the Aspergillus section Fumigati are the most frequently occurring agents, but depending on the local epidemiology, representatives of section Terrei or section Flavi are the second or third most important. Aspergillus terreus species complex is of great interest, as it is usually amphotericin B resistant and displays notable differences in immune interactions in comparison to Aspergillus fumigatus. The latest epidemiological surveys show an increased incidence of A. terreus as well as an expanding clinical spectrum (chronic infections) and new groups of at-risk patients being affected. Hallmarks of these non-Aspergillus fumigatus invasive mold infections are high potential for tissue invasion, dissemination, and possible morbidity due to mycotoxin production. We seek to review the microbiology, epidemiology, and pathogenesis of A. terreus species complex, address clinical characteristics, and highlight the underlying mechanisms of amphotericin B resistance. Selected topics will contrast key elements of A. terreus with A. fumigatus. We provide a comprehensive resource for clinicians dealing with fungal infections and researchers working on A. terreus pathogenesis, aiming to bridge the emerging translational knowledge and future therapeutic challenges on this opportunistic pathogen. |
| Databáze: | OpenAIRE |
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