Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events

Autor: Zahi A. Fayad, John E. Postley, Silvia H. Aguiar, Paul Muntner, Sameer Bansilal, Hiroaki Taniguchi, Samuel S. Gidding, Rob J. van der Geest, Johan H. C. Reiber, Mark Woodward, Karen B Weinshelbaum, Hamza El Aidi, Venkatesh Mani, Valentin Fuster, Michael E. Farkouh
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Carotid Artery Diseases
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Aortic Diseases
Lumen (anatomy)
Aorta
Thoracic
Coronary Artery Disease
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine.artery
Image Interpretation
Computer-Assisted
medicine
Thoracic aorta
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
10. No inequality
Angiology
Aged
Medicine(all)
Aorta
Chi-Square Distribution
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Research
Magnetic resonance imaging
Middle Aged
3. Good health
Carotid Arteries
lcsh:RC666-701
Area Under Curve
Cardiology
Female
Radiology
Cardiology and Cardiovascular Medicine
business
Wall thickness
Chi-squared distribution
Mace
Zdroj: Journal of Cardiovascular Magnetic Resonance, Vol 11, Iss 1, p 10 (2009)
Journal of Cardiovascular Magnetic Resonance
ISSN: 1097-6647
Popis: Aims Patients with prior major cardiovascular or cerebrovascular events (MACE) are more likely to have future recurrent events independent of traditional cardiovascular disease risk factors. The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events. Methods and Results Black blood carotid and thoracic aorta images were obtained from 195 patients using a rapid extended coverage turbo spin echo sequence. CMR measures of plaque burden were obtained by tracing lumen and outer vessel wall contours. Patients with prior MACE had significantly higher MR plaque burden (wall thickness, wall area and normalized wall index) in carotids and thoracic aorta compared to those without prior MACE (Wall thickness carotids: 1.03 ± 0.03 vs. 0.93± 0.03, p = 0.001; SD wall thickness carotids: 0.137 ± 0.0008 vs. 0.102 ± 0.0004, p < 0.001; wall thickness aorta: 1.63 ± 0.10 vs. 1.50 ± 0.04, p = 0.009; SD wall thickness aorta: 0.186 ± 0.035 vs. 0.139 ± 0.012, p = 0.009 respectively). Plaque burden (wall thickness) and plaque eccentricity (standard deviation of wall thickness) of carotid arteries were associated with prior MACE after adjustment for age, sex, and traditional risk factors. Area under ROC curve (AUC) for discriminating prior MACE improved by adding plaque eccentricity to models incorporating age, sex, and traditional CVD risk factors as model inputs (AUC = 0.79, p = 0.05). Conclusion A greater plaque burden and plaque eccentricity is prevalent among patients with prior MACE.
Databáze: OpenAIRE
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