Alterations of pRb1-cyclin D1-cdk4/6-p16INK4A pathway in endometrial carcinogenesis
| Autor: | Jerzy Andrzej Jakowicki, Andrzej Semczuk |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Cell Cycle Proteins medicine.disease_cause Retinoblastoma Protein Metastasis Cyclin D1 Uterine cancer Neoplasms Proto-Oncogene Proteins Tumor Cells Cultured medicine Humans neoplasms Cyclin-Dependent Kinase Inhibitor p16 integumentary system biology Cyclin-dependent kinase 4 Cell Cycle Retinoblastoma protein Cyclin-Dependent Kinase 4 Cell cycle medicine.disease Cyclin-Dependent Kinases Oncology biology.protein Cancer research Female Cyclin-dependent kinase 6 Carcinogenesis |
| Zdroj: | Cancer Letters. 203:1-12 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2003.09.012 |
| Popis: | The retinoblastoma protein pathway (pRb1-cyclin D1-cdk4/6-p16(INK4A)) participates in the regulation of the cellular processes at the transition of G1/S phases of the cell-cycle. Derailments of this pathway, caused either by lack of pRb1 or p16(INK4A) expression or overexpression of cyclin D1 and/or cdk4/6, are implicated in the deregulation of the cell-cycle machinery, resulting in uncontrolled cell proliferation, tumor heterogeneity, invasion and metastasis. Several studies conducted so far have assessed the deregulation of the pRb1-pathway components in various human tumors and cell-lines, provided these pathway alterations play an obligatory role in tumorigenesis. This review briefly summarizes the current information on the pRb1-cyclin D1-cdk4/6-p16(INK4A) alterations in sporadic uterine cancer, placing emphasis on the influence on the dualistic model of endometrial carcinogenesis. |
| Databáze: | OpenAIRE |
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