Isoflurane-Induced Burst Suppression Is a Thalamus-Modulated, Focal-Onset Rhythm With Persistent Local Asynchrony and Variable Propagation Patterns in Rats
| Autor: | Jing Li, Shujia Xu, Dan Li, Peijuan Luo, Fan Yang, Theodore H. Schwartz, Qingchen Zhou, Hongtao Ma, Weihong Lin, Chaojia Chu, Dan Wu, Jianmin Liang, Kane O. Pryor, Qianwen Ming, Jyun-you Liou |
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| Rok vydání: | 2021 |
| Předmět: |
Cognitive Neuroscience
Thalamus Neuroscience (miscellaneous) Biology lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Calcium imaging Rhythm Developmental Neuroscience Cortex (anatomy) thalamocortical interactions medicine traveling wave lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research 030304 developmental biology widefield calcium imaging 0303 health sciences Neocortex slow oscillations general anesthesia Burst suppression medicine.anatomical_structure chemistry Isoflurane Tetrodotoxin burst suppression Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Systems Neuroscience Frontiers in Systems Neuroscience, Vol 14 (2021) |
| ISSN: | 1662-5137 |
| DOI: | 10.3389/fnsys.2020.599781 |
| Popis: | Background: Inhalational anesthetic-induced burst suppression (BS) is classically considered a bilaterally synchronous rhythm. However, local asynchrony has been predicted in theoretical studies and reported in patients with pre-existing focal pathology.Method: We used high-speed widefield calcium imaging to study the spatiotemporal dynamics of isoflurane-induced BS in rats.Results: We found that isoflurane-induced BS is not a globally synchronous rhythm. In the neocortex, neural activity first emerged in a spatially shifting, variably localized focus. Subsequent propagation across the whole cortex was rapid, typically within Conclusion: The classical impression that anesthetics-induced BS is a state of global brain synchrony is inaccurate. Bursts are a series of shifting local cortical events facilitated by thalamic projection that unfold as rapid, bilaterally asynchronous propagating waves. |
| Databáze: | OpenAIRE |
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